Optimizing CNS DHA Delivery in Elderly Adults at Risk for Dementia

Eligibility Criteria

• 1. men and women 62 to 80 years old;
• 2. presence of subjective cognitive decline using the SCD questionnaire, DEX and EMQ, education-adjusted MoCA score of \>23 \[106,107\]; CVLT cumulative acquisition score \>1.5 SD below the age-adjusted mean, and preservation of independence in functional abilities, as corroborated by an informant providing information on the mCDR \[108\];
• 3. No contraindication to a lumbar puncture (e.g., thrombocytopenia, coagulopathy, concomitant use of anticoagulant medications, etc.);
• 4. fluency in English;
• 5. ability to comprehend and comply with the research protocol; and
• 6. provision of written informed consent.
• 1. diagnosis of MCI, AD, Parkinson's disease, frontotemporal dementia, multi-infarct dementia, significant head trauma, epilepsy, leukoencephalopathy, or other neurological condition;
• 2. self-reported emotional disorder such as severe depression or other psychiatric condition causing a persisting decline in functional capability;
• 3. diagnosis of diabetes, pancreatic, liver, kidney or hematological coagulation disorder;
• 4. allergy to shellfish or seafood;
• 5. current or past substance use causing physiological dependence or persisting change in functional capability;
• 6. concomitant, regular use of medications that might affect outcome measures or adversely interact with the study product including anticoagulant medications;
• 7. weekly fish consumption \>1 x 3 oz servings and/or use of DHA-containing supplements within 3 months prior to screening.