Effects of Distinct Nebraska-Dry Bean Market Classes on Gut Microbiota

Description

Beans are well known for their health benefits. Many of these benefits relate to gut health, as many of the nutrients found in beans support beneficial microbes that live in the gut. However, beans have a lot of genetic diversity. This diversity has led to different bean market classes with different colors, sizes, and nutrient profiles. Differences between bean market classes may trigger different effects on gut microbes and health, but this is poorly understood. The goal of the pilot clinical trial is to make comparisons (1) between two different bean market classes (pink beans, great northern beans) and (2) between a bean mixture (pinto, kidney, black, pink, and great northern beans) and individual bean market classes. The study will assess whether bean market classes differ in their effects on gut microbes, blood pressure, metabolism, and gut symptoms in adults with and without obesity.

Conditions

Dietary Intervention, Gut Microbiota

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Study Overview

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Study Details

Study overview

Beans are well known for their health benefits. Many of these benefits relate to gut health, as many of the nutrients found in beans support beneficial microbes that live in the gut. However, beans have a lot of genetic diversity. This diversity has led to different bean market classes with different colors, sizes, and nutrient profiles. Differences between bean market classes may trigger different effects on gut microbes and health, but this is poorly understood. The goal of the pilot clinical trial is to make comparisons (1) between two different bean market classes (pink beans, great northern beans) and (2) between a bean mixture (pinto, kidney, black, pink, and great northern beans) and individual bean market classes. The study will assess whether bean market classes differ in their effects on gut microbes, blood pressure, metabolism, and gut symptoms in adults with and without obesity.

Effects of Distinct Nebraska-Dry Bean Market Classes on Gut Microbiota

Effects of Distinct Nebraska-Dry Bean Market Classes on Gut Microbiota

Condition
Dietary Intervention
Intervention / Treatment

-

Contacts and Locations

Lincoln

Nebraska Food for Health Center, Lincoln, Nebraska, United States, 68588

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Aged 19 to 50 years.
  • 2. Not currently pregnant or planning to become pregnant (Females Only).
  • 3. Stable body mass index (BMI) of either 18.5-24.9 kg/m2 or 27.0-39.9 kg/m2 for the last month.
  • 4. Has not made any major dietary changes in the last month.
  • 5. Able to read and speak English
  • 6. Requires no legally authorized representative (LAR).
  • 7. Not institutionalized (e.g., prison, psychological treatment center, etc.).
  • 8. Able to wear ambulatory blood pressure monitor and limit physical activity over a 24-hr. period.
  • 9. Have a bowel movement at least every other day.
  • 10. Able to collect and deliver stool samples to Innovation Campus within 4 hours of collection.
  • 11. No known allergies or intolerance to beans.
  • 12. Able to avoid consuming beans during the study, except for the provided beans (up to 1.5 cups/day).
  • 1. Has a cardiac device.
  • 2. History of organ transplant
  • 3. History of gastrointestinal surgery or disease diagnosed by a physician that involves the stomach, small, and large intestines (e.g., IBD, IBS, chronic constipation, diverticulosis, gastric bypass).
  • 4. Recent history of cancer (excluding skin cancer) in the last year.
  • 5. Current use of tobacco or vaping.
  • 6. Current or recent use (last 3 weeks) of digestive enzymes, laxatives, dietary fiber, prebiotic, or probiotic supplements.
  • 7. Medication or supplement regimen or dosage changed within the last 2 months or 3 weeks, respectively.
  • 8. Taken antibiotics in the last 2 months.
  • 9. Known allergies or intolerances to beans.
  • 10. BMI 18.5-24.9 kg/m2 (normoweight): Current use of oral or injectable medications for the treatment of most chronic conditions.
  • 11. BMI 27.0-39.9 kg/m2 (overweight): Current use of oral or injectable medications for the treatment of diabetes, hypertension, cardiovascular, liver, kidney, gastrointestinal, or autoimmune.

Ages Eligible for Study

19 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Nebraska Lincoln,

Edward C Deehan, PhD, RD, PRINCIPAL_INVESTIGATOR, University of Nebraska Lincoln

Study Record Dates

2027-04-30