Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

Description

The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps. Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.

Conditions

Polyp of Colon, Endoscopic Mucosal Resection

Study Overview

Study Details

Study overview

The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps. Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

Condition
Polyp of Colon
Intervention / Treatment

-

Contacts and Locations

Weston

Cleveland Clinic Weston, Weston, Florida, United States, 33331

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patient (age 18 years or older)
  • * Polyp size of at least 20 mm
  • * - Morphology: Flat or superficially raised polyp morphology (i.e., Paris classification 1s, 0-IIa or 0-IIb, or a combination of the above)
  • * Polyps with previous failed resection attempts or polyp recurrence
  • * Suspected deep submucosal invasion on endoscopic assessment of surface mucosal pit pattern (Kudo V or NICE 3 pattern) or histologically confirmed malignancy (invasive adenocarcinoma)
  • * Polyps with nodules too large (\>1-1.5cm) for the use of a cold snare
  • * Inflammatory bowel disease

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Tilak Shah, M.D., PRINCIPAL_INVESTIGATOR, Cleveland Clinic Florida (Weston Hospital)

Study Record Dates

2026-12