RECRUITING

Study of 225Ac-SS0110 in Subjects With ES-SCLC or MCC (SANTANA-225 )

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to determine safety, tolerability, recommended phase 2 dose (RP2D), and preliminary antitumor activity of 225Ac-SSO110 with standard of care (SoC) therapy in patients with somatostatin receptor 2 expressing (SSTR2+) extensive-stage small cell lung cancer (ES-SCLC) and recurrent locally advanced or metastatic Merkel cell carcinoma (MCC).

Official Title

A Multicentre, Open-label, Phase I/II Study Investigating the Safety, Tolerability, and Preliminary Efficacy of 225Ac-SSO110 in Participants With Extensive Stage Small Cell Lung Cancer (ES-SCLC) or Merkel Cell Carcinoma (MCC) Receiving Standard of Care (SoC)

Quick Facts

Study Start:2025-04
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06939036

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Ariceum Therapeutics Clinical Trials
CONTACT
+49 30 94 89 3360
clinical@ariceum-therapeutics.com

Study Locations (Sites)

Biogenix Molecular
Miami, Florida, 33165
United States

Collaborators and Investigators

Sponsor: Ariceum Therapeutics GmbH

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04
Study Completion Date2026-12

Study Record Updates

Study Start Date2025-04
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • actinium
  • 225Ac
  • actinium-225
  • SSO110
  • SSO120
  • gallium
  • 68Ga
  • gallium-68
  • radiopharmaceutical
  • MCC
  • Merkel Cell carinoma
  • ES-SCLC
  • Extensive Stage Small Cell Lung Cancer
  • radioligand
  • somatostatin receptor 2
  • JR11
  • sstr2-antagonist

Additional Relevant MeSH Terms

  • Small Cell Lung Cancer Extensive Stage
  • Merkel Cell Carcinoma