Intraoperative Parathyroid Gland (PTG) Identification Using a Hand-Held Imager (HHI)

Description

It is often challenging to tell apart the parathyroid glands from the surrounding area such as lymph nodes, fat and thyroid tissue. If the surgeons are not able to tell where the parathyroid glands are, they might accidentally be removed or damaged. This can lead to complications such as hypocalcemia (low calcium level) requiring treatment and sometimes lead to longer hospital stay. This study is designed to test a new method (a non-invasive hand-held imaging device) to assist surgeons in identifying the parathyroid glands, in order to decrease the rate of post-operative complication.

Conditions

Thyroid Disease, Thyroid Surgery, Parathyroid Gland

Study Overview

Study Details

Study overview

It is often challenging to tell apart the parathyroid glands from the surrounding area such as lymph nodes, fat and thyroid tissue. If the surgeons are not able to tell where the parathyroid glands are, they might accidentally be removed or damaged. This can lead to complications such as hypocalcemia (low calcium level) requiring treatment and sometimes lead to longer hospital stay. This study is designed to test a new method (a non-invasive hand-held imaging device) to assist surgeons in identifying the parathyroid glands, in order to decrease the rate of post-operative complication.

Early Feasibility Study on Intraoperative Parathyroid Gland (PTG) Identification Using a Hand-Held Imager (HHI)

Intraoperative Parathyroid Gland (PTG) Identification Using a Hand-Held Imager (HHI)

Condition
Thyroid Disease
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins Hospital, Baltimore, Maryland, United States, 21287

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Diagnosis of thyroid tumors, or other conditions requiring thyroid surgery where frozen section biopsy of PTGs is deemed necessary under the surgeon's estimation.
  • * Plan for surgical resection of pathological PTGs.
  • * Subject age 18 - 70 yo.
  • * Subject agreement to participate
  • * Not eligible for endocrine surgeries
  • * Plan for biopsy only of thyroid tumor (likely difficult to obtain sufficient tissue for both pathology analysis and study assessment)
  • * Subject age younger than 18 yo or older than 70 yo
  • * Subject refusal to participate
  • * Subject cognitively impaired and/or unable to provide assent.
  • * Allergy to indocyanine green and iodine.

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

OPTOSURGICAL, LLC,

Kaitlyn Frazier, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2025-12-30