Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

Description

This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony.

Conditions

Alzheimer Disease, Dementia, Mild Cognitive Impairment, Peer-bonded Caregiver, Caregiver

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Study Overview

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Study Details

Study overview

This study aims to investigate the neurophysiological effects of live music on individuals with early Alzheimer's Disease (AD), dementia, and/or mild cognitive impairment (MCI) and their caregivers. Heart rate (HR), heart rate variability (HRV), and brain activity will be measured as participant-caregiver dyads listen to preferred and improvised music performed by professional musicians. Investigators will leverage various measurement techniques including, but not limited to, electroencephalography (EEG), behavioral, surveys, and physiological monitoring to study the impact of live music on anxiety in AD and inter-dyad synchrony.

Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

Neurophysiological Benefits of Live Music for Early Alzheimer's Patients and Their Caregivers

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

New Haven

Firehouse 12 Studios, New Haven, Connecticut, United States, 06510

New Haven

Musical Intervention Studios, New Haven, Connecticut, United States, 06520

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Clinical Dementia Rating 0.5 - 2
  • * Be a person with or caregiver to a person with a diagnosis of early Alzheimer's Disease, mild dementia, and/or mild cognitive impairment (MCI)
  • * Able to provide informed consent
  • * Willing to wear an EEG headset and heart rate monitoring devices
  • * Willing to possibly have small patches of body / facial hair shaved to accommodate administration of heart rate monitoring devices
  • * Willing to answer survey questions about topics related to the study
  • * Willing to be audio / video recorded
  • * Clinical Dementia Rating \<0.5 or \> 2
  • * Unable to provide informed consent
  • * Endorsing suicidal ideation (SI), self-injurious behavior, or homicidal ideation (HI) above the threshold defined in the "Risk Reduction and Safety Plan"
  • * Participating in another clinical trial studying AD and/or Dementia
  • * Starting a new prescription medication in the last 6 months
  • * Prescribed Benzodiazepines on an as needed basis

Ages Eligible for Study

50 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

AZA Allsop, MD, PhD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2025-08