Vaping and Smoking Project in People With Schizophrenia

Description

The proposed research will characterize withdrawal among people with schizophrenia who vape daily compared to people with schizophrenia who smoke combustible cigarettes daily, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence and contributing to the development of vaping cessation interventions amongst people with schizophrenia, the leading preventable cause of death in the US.

Conditions

Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

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Study Overview

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Study Details

Study overview

The proposed research will characterize withdrawal among people with schizophrenia who vape daily compared to people with schizophrenia who smoke combustible cigarettes daily, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence and contributing to the development of vaping cessation interventions amongst people with schizophrenia, the leading preventable cause of death in the US.

A Laboratory Study of Behavior and Performance Among People Who Vape Nicotine and/or Smoke Cigarettes - Schizophrenia Supplement

Vaping and Smoking Project in People With Schizophrenia

Condition
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Intervention / Treatment

-

Contacts and Locations

Buffalo

University at Buffalo, Buffalo, New York, United States, 14260

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 6+ months of daily/near-daily nicotine vaping or cigarette smoking
  • * 200+ ng/mL cotinine on a commercially-available quick screen
  • * stable antipsychotic medication dose (no changes in past 6 months).
  • * intention to quit daily/near-daily vaping/smoking in the next month
  • * current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
  • * current use of any smoking cessation medication
  • * current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
  • * current (past 2 weeks) suicidal ideation with intent and/or plan
  • * pregnancy (intake urine screen)
  • * florid psychosis or severe cognitive symptoms (score of ≥5 on PANSS items delusions (P1), hallucinatory behavior (P3), or unusual thought content (G9), conceptual disorganization (P2), abstract thinking (N5), or poor attention (G11) or a score ≥6 on grandiosity (P5) or suspiciousness (P6)

Ages Eligible for Study

21 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

State University of New York at Buffalo,

Larry Hawk, PhD, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

2027-04-01