RECRUITING

A Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The main purpose of this study is to evaluate the safety, tolerability of LY4086940 and how it is processed in the body. Participation in Part A of the study will last about 10 weeks and may include up to 6 visits. Participation in Parts B, C, D will last approximately 15 weeks and may include up to 9 visits. Participation in Part E will last approximately 7 weeks and may include up to 12 visits.

Official Title

A Single-Dose and Multiple-Ascending Dose Study of LY4086940 in Healthy Participants and Participants With Overweight or Obesity, With or Without Type 2 Diabetes

Quick Facts

Study Start:2025-04-23
Study Completion:2026-04
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06945419

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Have no significant body weight change for the 3 months prior to screening
  2. * Are considered healthy
  3. * Have a body mass index (BMI) of 22 to 35 kilograms per square meter (kg/m2) at screening
  4. * Have a BMI of 27 to 45 kg/m2 at screening
  5. * Have a BMI of 25 to 45 kg/m2 at screening
  6. * Have type 2 diabetes
  7. * Have hemoglobin A1C (HbA1c) ≥7.0% and ≤10.5% at screening
  8. * Have a BMI of 27 to 45 kg/m2 at screening
  1. * Have had an acute cardiovascular condition within the past 6 months prior to screening
  2. * Have liver disease or pancreatitis
  3. * Have used medications for weight loss within the 3 months prior to screening
  4. * Have any form of diabetes
  5. * Have type 1 diabetes

Contacts and Locations

Study Contact

Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
1-317-615-4559
LillyTrials@Lilly.com
Physicians interested in becoming principal investigators please contact
CONTACT
clinical_inquiry_hub@lilly.com

Principal Investigator

Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST)
STUDY_DIRECTOR
Eli Lilly and Company

Study Locations (Sites)

Fortrea Clinical Research Unit
Daytona Beach, Florida, 32117
United States
Fortrea Clinical Research Unit
Dallas, Texas, 75247
United States
Endeavor Clinical Trials
San Antonio, Texas, 78240
United States

Collaborators and Investigators

Sponsor: Eli Lilly and Company

  • Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), STUDY_DIRECTOR, Eli Lilly and Company

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-23
Study Completion Date2026-04

Study Record Updates

Study Start Date2025-04-23
Study Completion Date2026-04

Terms related to this study

Keywords Provided by Researchers

  • Oral
  • Incretin
  • Weight loss
  • Overweight
  • Obesity
  • Diabetes

Additional Relevant MeSH Terms

  • Healthy
  • Overweight
  • Obesity
  • Type 2 Diabetes