Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis

Description

The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days following a laparoscopic appendectomy for complicated appendicitis. Feasibility will be determined by high compliance and adherence of patients to the postoperative instructions, while safety will be assessed by the incidence of postoperative infectious complications and requirement for re-admission.

Conditions

Appendicitis Acute, Appendicitis Perforated, Appendicitis With Perforation, Appendicitis Suppurative, Appendicitis Gangrenous

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Study Overview

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Study Details

Study overview

The exploratory objective of this pilot study is to evaluate the feasibility and safety of an enhanced recovery protocol that will allow adult patients to be discharged to home on an oral antibiotic regimen for three days following a laparoscopic appendectomy for complicated appendicitis. Feasibility will be determined by high compliance and adherence of patients to the postoperative instructions, while safety will be assessed by the incidence of postoperative infectious complications and requirement for re-admission.

Enhanced Recovery Protocol for Acute, Complicated Appendicitis After Laparoscopic Appendectomy: An Exploratory Pilot Study

Enhanced Recovery After Surgery (ERAS) for Complicated Appendicitis

Condition
Appendicitis Acute
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Individuals between the ages of 18 and 65 years of age.
  • * Patients undergoing a laparoscopic appendectomy.
  • * Diagnosis of complicated appendicitis based on pre-operative imaging or intra-operative assessment. The definition of a complicated appendicitis will include: (a) perforated appendicitis, without generalized peritonitis; (b) gangrenous appendicitis, without generalized peritonitis; (c) suppurative appendicitis; (d) iatrogenic perforation of the appendix.
  • * Meet criteria for discharge from the post-anesthesia care unit (PACU).
  • * Ability to reliably follow up with the study procedures.
  • * Age \< 18 years or \> 65 years.
  • * Pregnancy.
  • * Homelessness.
  • * Patients who present with generalized peritonitis.
  • * Patients with comorbid conditions, including diabetes mellitus, immunosuppressed state for any reason, patients on chronic anticoagulation (excluding Aspirin 81 mg).
  • * Patients who present with septic shock.
  • * Patients who require conversion to an open appendectomy.
  • * Patients who present with additional findings on imaging studies or intra-operatively, including ileus or small bowel obstruction.
  • * Based on surgeon's clinical judgment for reasons that may not be outlined above.
  • * Allergy or intolerance to study medication(s)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Cedars-Sinai Medical Center,

Galinos Barmparas, MD, PRINCIPAL_INVESTIGATOR, Cedars-Sinai Medical Center

Study Record Dates

2026-02-28