RECRUITING

Acute Effects of THC in Older Adult

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.

Official Title

Acute Effects of THC in Older Adult

Quick Facts

Study Start:2025-06-06
Study Completion:2027-11-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06948136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Deepak C D'Souza
CONTACT
203-932-5711
deepak.douza@yale.edu
Ashley Schnakenberg Martin, PhD
CONTACT
ashley.martin@yale.edu

Principal Investigator

Deepak C D'Souza, MD
PRINCIPAL_INVESTIGATOR
Yale University School of Medicine; VA Connecticut Healthcare System
Ashley Schnakenberg Martin, PhD
PRINCIPAL_INVESTIGATOR
Yale University School of Medicine; VA Connecticut Healthcare System

Study Locations (Sites)

VA Connecticut Healthcare System
West Haven, Connecticut, 06516
United States

Collaborators and Investigators

Sponsor: Yale University

  • Deepak C D'Souza, MD, PRINCIPAL_INVESTIGATOR, Yale University School of Medicine; VA Connecticut Healthcare System
  • Ashley Schnakenberg Martin, PhD, PRINCIPAL_INVESTIGATOR, Yale University School of Medicine; VA Connecticut Healthcare System

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-06
Study Completion Date2027-11-01

Study Record Updates

Study Start Date2025-06-06
Study Completion Date2027-11-01

Terms related to this study

Additional Relevant MeSH Terms

  • Age-related Cognitive Decline