RECRUITING

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to establish risk factors for post-transplant in adult individuals with cirrhosis without diabetes undergoing liver transplant evaluation. The question being addressed is: can laboratory work, anthropometric tests, functional tests, imaging, and advanced measurements such as wrist actigraphy, continuous glucose monitoring, or oral glucose tolerance testing predict the development of diabetes after liver transplant? Participants will be asked to periodically participate in wearing a continuous glucose monitor and wrist actigraph and obtain an oral glucose tolerance test both before and after liver transplant.

Official Title

Changes in Glucose Tolerance in Patients With Cirrhosis Peri-Liver Transplant

Quick Facts

Study Start:2024-03-12
Study Completion:2031-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06950788

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients presenting to liver transplant clinic with a diagnosis of cirrhosis.
  2. * Age \>18 yrs.
  3. * Ability to understand and sign written consent form, or have a legally-authorized representative or proxy who can be approached for consent
  1. * Patients without consent
  2. * Patients with implantable cardioverter defibrillator devices or automated implantable cardioverter defibrillator devices will be excluded from the bio-electrical impedance analysis portion of the measurements.
  3. * Patients with unremovable electrical medical devices or devices that cannot turn off will be excluded from the bio-electrical impedance analysis measurements
  4. * Pregnant patients
  5. * Incarcerated patients
  6. * Patients with a history of type 2 diabetes mellitus diagnosed \> 5 years ago will be excluded from the Oral Glucose Tolerance Test portion of the study

Contacts and Locations

Study Contact

Mary E Rinella, MD
CONTACT
7737021000
mrinella@bsd.uchicago.edu
Alan L Hutchison, MD PhD
CONTACT
Alan.Hutchison@uchicagomedicine.org

Principal Investigator

Mary E Rinella, MD
PRINCIPAL_INVESTIGATOR
University of Chicago

Study Locations (Sites)

University of Chicago Medical Center
Chicago, Illinois, 60637
United States

Collaborators and Investigators

Sponsor: University of Chicago

  • Mary E Rinella, MD, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-12
Study Completion Date2031-01

Study Record Updates

Study Start Date2024-03-12
Study Completion Date2031-01

Terms related to this study

Keywords Provided by Researchers

  • Cirrhosis
  • Post-transplant diabetes
  • New-onset diabetes after transplant
  • Liver transplantation

Additional Relevant MeSH Terms

  • Cirrhosis, Liver
  • Diabetes Mellitus Risk
  • Transplant; Failure, Liver
  • Transplant-Related Disorder