Imaging Biomarkers of FOG Response to DBS

Description

For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS, participants will undergo an MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS, participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.

Conditions

Freezing of Gait Symptoms in Parkinson's Disease, Deep Brain Stimulation

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Study Details

Study overview

For this study, the investigators are recruiting 54 individuals with Parkinson's Disease and Freezing of Gait (FOG) who are planning to undergo Deep Brain Stimulation (DBS). The objective of this study is to better understand the FOG response to DBS. Prior to DBS, participants will undergo an MRI scan, behavioral assessment related to walking, a cognitive evaluation, and assessment of other Parkinson's disease symptoms. Following DBS, participants will repeat these assessments at multiple timepoints over the period of one year. Overall, participants will complete a total of 7 visits over a period of approximately 1 year.

Imaging Biomarkers of Freezing of Gait Response to Deep Brain Stimulation

Imaging Biomarkers of FOG Response to DBS

Condition
Freezing of Gait Symptoms in Parkinson's Disease
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina, Charleston, South Carolina, United States, 29425

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. \>40 years of age.
  • 2. diagnosis of PD based on UK Brain Bank diagnostic criteria.
  • 3. presence of FOG, defined as a score of 1 on part 1 of the nFOGQ and confirmed by objective evaluation (a score of 1 represents a positive response of having experienced such an episode over the last month).
  • 4. clinically selected at the MUSC DBS Conference to undergo STN-DBS surgery.
  • 1. a history of other significant gait impairment unrelated to PD (e.g. orthopedic deformities).
  • 2. inability to complete gait assessments (timed-up-and-go task) in the OFF state without assistance or assist devices.
  • 3. contraindications to MRI, including inability to lie supine in the scanner environment, pregnancy, and non-MRI compatible metal implants.
  • 4. implantation of non-3 T MRI-compatible DBS devices.

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical University of South Carolina,

Study Record Dates

2030-01