Transcranial Magnetic Stimulation in Misophonia

Description

The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.

Conditions

Misophonia

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Study Overview

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Study Details

Study overview

The purpose of the project is to assess the efficacy of parietal transcranial magnetic stimulation in misophonia. N=60 participants will undergo two transcranial magnetic stimulation sessions: one inhibitory and another excitatory. During both sessions, the parietal region will be stimulated. Participants will perform computerized tasks immediately before and after the stimulation, while EEG, heart rate, and skin temperature will be recorded. These recordings will be used to assess if TMS can be used to improve tolerance to misophonia triggers.

A Transcranial Magnetic Stimulation Approach to Treat Misophonia

Transcranial Magnetic Stimulation in Misophonia

Condition
Misophonia
Intervention / Treatment

-

Contacts and Locations

New York

Mount Sinai West, New York, New York, United States, 10022

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Hypersensitive to presence of a specific sound, which may be accompanied by irritation, anger/outbursts, or fear.
  • * Must be between the ages of 18 - 55.
  • * Must be fluent in English since the study's instructions, surveys, and tasks will be in English.
  • * Axis I Psychiatric condition, past or present, as defined in DSM-V.
  • * Disability or medical condition that prohibits completion of study. Participants must be able to complete all study procedures to ensure optimal conditions for data analysis.
  • * Central Nervous System (CNS) disease, such as history of brain abnormalities (e.g., neoplasms, subarachnoid cysts), cerebrovascular disease, infectious disease (e.g., abscess), or other neurological diseases, history of head trauma (defined as loss of consciousness\>3 min), or history of seizures without a resolved etiology. CNS disease and drugs that act in the peripheral or central nervous system are likely to have effects on patterns of neural activity.
  • * Recent or regular use of psychotropic medication (e.g., amitriptyline for migraines).
  • * Recent use of drugs of abuse.
  • * Presence of any mental implants in the head.
  • * Pregnant or lactating.

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Icahn School of Medicine at Mount Sinai,

Parul Jain, PhD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai

Study Record Dates

2026-06-30