RECRUITING

Comparison of I-124 PET/CT for the Diagnosis of Thyroid Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Persons diagnosed with thyroid cancer are often treated initially with a thyroidectomy, which is followed by ablation using Iodine-131, a therapy which has been shown to be effective and safe. Imaging of metastatic thyroid cancer has been performed with whole body I-131 and Iodine 123 (I-123) imaging for many decades and use I-123 for staging studies. Iodine 124 (I-124) is a radioisotope of iodine which emits a positron and is imaged using PET (positron emission tomography). This is a single arm prospective trial that evaluates the ability of Iodine-124 (I-124) to detect metastatic thyroid cancer compared to non-interventional, usual care I-123 and I-131 images.

Official Title

Comparison of I-124 PET/CT to I-123 Whole Body Imaging for the Diagnosis of Thyroid

Quick Facts

Study Start:2025-07-14
Study Completion:2026-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06961084

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Age \>= 18 years.
  2. 2. Histopathologically confirmed differentiated thyroid cancer, with clinical concern for metastatic disease, which is based on:
  3. 1. Metastatic disease seen on I-123 SPECT, Fluorodeoxyglucose (FDG) PET, CT scan or ultrasound.
  4. 2. Elevated thyroglobulin in participant after total thyroidectomy.
  5. 3. Planned I-123 imaging within 45 days after enrollment.
  6. 4. Ability to understand a written informed consent document, and the willingness to sign it.
  1. 1. Unlikely to comply with study procedures, restrictions and requirements and judged by the Investigator to be unsuitable for participation.
  2. 2. Known pregnancy, per institutional policy.

Contacts and Locations

Study Contact

Maya Aslam
CONTACT
(415) 514-8987
Maya.Aslam@ucsf.edu

Principal Investigator

Thomas Hope, MD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California, San Francisco
San Francisco, California, 94122
United States

Collaborators and Investigators

Sponsor: Thomas Hope

  • Thomas Hope, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-14
Study Completion Date2026-03-31

Study Record Updates

Study Start Date2025-07-14
Study Completion Date2026-03-31

Terms related to this study

Keywords Provided by Researchers

  • Imaging Studies

Additional Relevant MeSH Terms

  • Thyroid Cancer