Healthy Volunteers Study

Description

The purpose of this study is to examine the role of the bacterial environments and metabolites in the early detection and prediction of ovarian cancer development. Vaginal swabs and stool samples will be collected from healthy volunteers, or those without a known ovarian cancer diagnosis or genetic ovarian cancer risk. These samples will be compared to samples from participants with increased cancer risk and ovarian cancer diagnoses.

Conditions

Ovarian Cancer, Genetic Predisposition to Disease

Study Overview

Study Details

Study overview

The purpose of this study is to examine the role of the bacterial environments and metabolites in the early detection and prediction of ovarian cancer development. Vaginal swabs and stool samples will be collected from healthy volunteers, or those without a known ovarian cancer diagnosis or genetic ovarian cancer risk. These samples will be compared to samples from participants with increased cancer risk and ovarian cancer diagnoses.

Vaginal Metabolome Healthy Volunteers Study

Healthy Volunteers Study

Condition
Ovarian Cancer
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * has ovaries
  • * genetic mutations which increase risk of ovarian cancer: BRCA1/2, BRIP1, PALB2, Lynch Syndrome (MLH1, MSH2/EPCAM, MSH6) and ATM
  • * no genetic testing results or unknown genetic status
  • * prior cancer diagnosis
  • * prior cancer treatment
  • * HRT use
  • * Antibiotic use (1 month prior to providing sample)

Ages Eligible for Study

30 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Abramson Cancer Center at Penn Medicine,

Susan Domchek, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

2026-05-25