RECRUITING

Healthy Volunteers Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to examine the role of the bacterial environments and metabolites in the early detection and prediction of ovarian cancer development. Vaginal swabs and stool samples will be collected from healthy volunteers, or those without a known ovarian cancer diagnosis or genetic ovarian cancer risk. These samples will be compared to samples from participants with increased cancer risk and ovarian cancer diagnoses.

Official Title

Vaginal Metabolome Healthy Volunteers Study

Quick Facts

Study Start:2025-04-21
Study Completion:2026-05-25
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06962059

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years to 50 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * has ovaries
  1. * genetic mutations which increase risk of ovarian cancer: BRCA1/2, BRIP1, PALB2, Lynch Syndrome (MLH1, MSH2/EPCAM, MSH6) and ATM
  2. * no genetic testing results or unknown genetic status
  3. * prior cancer diagnosis
  4. * prior cancer treatment
  5. * HRT use
  6. * Antibiotic use (1 month prior to providing sample)

Contacts and Locations

Study Contact

Catherine Wolfe, BA
CONTACT
215-360-0422
catherine.wolfe@pennmedicine.upenn.edu
Jamie Brower, MS
CONTACT
215-662-7245
jabrower@pennmedicine.upenn.edu

Principal Investigator

Susan Domchek, MD
PRINCIPAL_INVESTIGATOR
University of Pennsylvania

Study Locations (Sites)

Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States

Collaborators and Investigators

Sponsor: Abramson Cancer Center at Penn Medicine

  • Susan Domchek, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-04-21
Study Completion Date2026-05-25

Study Record Updates

Study Start Date2025-04-21
Study Completion Date2026-05-25

Terms related to this study

Keywords Provided by Researchers

  • vaginal metabolome
  • ovarian cancer

Additional Relevant MeSH Terms

  • Ovarian Cancer
  • Genetic Predisposition to Disease