Mitigating Toxic Impact: The Role of Coenzyme Q10 in Post-Exposure Protection

Description

This research study is being conducted to see if coenzyme Q10 (a nutritional supplement) might help to prevent and/or alleviate symptoms and health consequences and help to improve quality of life and physical function in residents affected by the February 2023 East Palestine, Ohio train derailment. This is a pilot study that is not powered to achieve benefit but seek to examine effect size and variance to aid in power calculations for a potential future better powered study.

Conditions

Toxicant Induced Chronic Multisymptom Illness and Associated Symptoms and Comorbidities

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Study Overview

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Study Details

Study overview

This research study is being conducted to see if coenzyme Q10 (a nutritional supplement) might help to prevent and/or alleviate symptoms and health consequences and help to improve quality of life and physical function in residents affected by the February 2023 East Palestine, Ohio train derailment. This is a pilot study that is not powered to achieve benefit but seek to examine effect size and variance to aid in power calculations for a potential future better powered study.

Mitigating Toxic Impact: The Role of Coenzyme Q10 in Post-Exposure Protection

Mitigating Toxic Impact: The Role of Coenzyme Q10 in Post-Exposure Protection

Condition
Toxicant Induced Chronic Multisymptom Illness and Associated Symptoms and Comorbidities
Intervention / Treatment

-

Contacts and Locations

La Jolla

UC San Diego, La Jolla, California, United States, 92093

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * On Feb. 3, 2023, lived within 10 miles of the East Palestine, OH train derailment (closer in will receive preference). Others who were in the area for toxin mitigation and other reasons and show compatible symptoms will also be eligible.
  • * Meets Kansas symptom criteria for multi-symptom illness - originally defined for Gulf War Illness (has persistent symptoms, lasting greater than six months, that are of \>mild severity in at least three of the six domains of fatigue/sleep, pain, neurological/cognitive/mood, gastrointestinal, respiratory and dermatologic). At least some symptoms must be new or worsened since the derailment.
  • * Access to internet and smart phone or computer for remote Qualtrics survey participation.
  • * Willing to perform the stipulated study elements.
  • * Took ≥80% of run-in soft gels.
  • * Anticipated move from the area or other anticipated obstacle to participating for study duration.
  • * Participating in another clinical trial.
  • * Has a pre-existing health condition expected to produce significant and variable fluctuating symptoms (e.g. chronic infection and/or active cancer other than non-melanoma skin cancer).
  • * Contraindications to CoQ10, such as use of coumadin (although an interaction with CoQ10 is controversial).

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Beatrice A. Golomb, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, San Diego

Study Record Dates

2028-07-01