Multi-Cancer Detection Observational Cohort Study

Description

This study proposes a prospective observational registry study involving patients who have undergone clinical MCD testing at Mayo Clinic or referred to Mayo Clinic with Multi-Cancer Detection (MCD) test results for further evaluation and management.Novel, high-performance genomic technologies now allow detection of signals from cancers in the blood, giving rise to a new paradigm of MCD tests. Blood is inherently well suited for detection of cancer biomarkers as it contains circulating tumor cells and tumor cell-free DNA (cfDNA) that have been "shed" from an occult asymptomatic developing cancer. MCD tests analyze these genomic features of the circulating DNA, distinguish it from background signals and determine a site of tumor origin to guide subsequent testing to establish a firm cancer diagnosis (hopefully pre-symptomatic early stage and highly curable).

Conditions

Cancer

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Study Overview

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Study Details

Study overview

This study proposes a prospective observational registry study involving patients who have undergone clinical MCD testing at Mayo Clinic or referred to Mayo Clinic with Multi-Cancer Detection (MCD) test results for further evaluation and management.Novel, high-performance genomic technologies now allow detection of signals from cancers in the blood, giving rise to a new paradigm of MCD tests. Blood is inherently well suited for detection of cancer biomarkers as it contains circulating tumor cells and tumor cell-free DNA (cfDNA) that have been "shed" from an occult asymptomatic developing cancer. MCD tests analyze these genomic features of the circulating DNA, distinguish it from background signals and determine a site of tumor origin to guide subsequent testing to establish a firm cancer diagnosis (hopefully pre-symptomatic early stage and highly curable).

Multi-Cancer Detection Observational Cohort Study

Multi-Cancer Detection Observational Cohort Study

Condition
Cancer
Intervention / Treatment

-

Contacts and Locations

Scottsdale

Mayo Clinic in Arizona, Scottsdale, Arizona, United States, 85259

Jacksonville

Mayo Clinic in Florida, Jacksonville, Florida, United States, 32224-9980

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Has Mayo Clinic medical record number
  • * Has undergone (within last 6 months) or scheduled to undergo a multi-cancer detection test (MCD) as ordered by provider
  • * Able to provide informed consent
  • * ≥ 21 years old
  • * Ability to provide blood sample
  • * Individuals who have situations that would limit compliance with the study requirements
  • * Institutionalized (i.e. Federal Medical Prison)
  • * Known pregnancy (self-reported)
  • * Currently undergoing active cancer treatment other than adjuvant hormone therapy
  • * Invasive cancer diagnosis within the last 3 years

Ages Eligible for Study

21 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Jewel Samadder, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2029-06-30