Study of IBI3020 Treatment in Participants With Late-Stage Solid Tumors

Eligibility Criteria

• 1. Participants have the ability to understand and give written informed consent for participation in this trial, including all evaluations and procedures as specified by this protocol;
• 2. Male or female participants ≥ 18 years old. For Part 1, age ≥ 18 years and ≤ 75 years;
• 3. Histologically or cytologically confirmed unresectable, locally advanced or metastatic solid tumors which have received available standard therapies and have disease progression, or unacceptable toxic effects, or contraindications;
• 4. At least 1 measurable lesion as defined per RECIST v1.1 within 28 days prior to the first dose of IBI3020;
• 5. Eastern Cooperative Oncology Group (ECOG) Performance Status score of 0-1;
• 6. Minimum life expectancy of 12 weeks;
• 7. Adequate bone marrow and organ function confirmed at screening period;
• 8. Participants, both male and female, who are not of childbearing potential or who agree to use at least 1 highly effective method of contraception during the study.
• 1. Previous treatment with CEACAM5-targeted therapy;
• 2. Prior anti-cancer therapy within the wash-out period;
• 3. Received live vaccines within 4 weeks or cancer vaccine within 3 months;
• 4. Potent cytochrome P450 3A4 (CYP3A4) inhibitors within 2 weeks or 5 half-lives;
• 5. Has adverse reactions resulting from previous anti-tumor therapies, which have not resolved to Grade 0 or 1 toxicity according to NCI CTCAE v5.0;
• 6. Known allergies, hypersensitivity, or intolerance to IBI3020 or its excipients;
• 7. Undergone major surgery within 4 weeks, or who have severe unhealed wounds;
• 8. Known symptomatic central nervous system (CNS) metastases;
• 9. Uncontrolled diseases or conditions;
• 10. History of pneumonitis requiring corticosteroids therapy, or history of clinically significant lung diseases;
• 11. History of thromboembolic event within 6 months;
• 12. Under neurological, psychiatric or social condition;
• 13. Women who are pregnant, have positive results in pregnancy test or are lactating;
• 14. Not eligible to participate in this study at the discretion of the investigator;
• 15. Participating in any other interventional clinical research.