RECRUITING

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.

Official Title

An Open-label, Phase 1 Study of DCC-2812 Monotherapy in Participants With Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer

Quick Facts

Study Start:2025-08
Study Completion:2029-02
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06966024

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer
  2. * Able to take oral medication
  3. * If a female is of childbearing potential, must have a negative pregnancy test prior to enrollment and all participants agree to follow the contraception requirements
  4. * Adequate organ function and electrolytes
  1. * Received any prior anticancer therapy or any investigational therapy within a specified timeframe prior to first dose of DCC-2812
  2. * Impaired cardiac function
  3. * Major surgery within 28 days of the first dose of study drug

Contacts and Locations

Study Contact

Clinical Team
CONTACT
785-830-2100
clinicaltrials@deciphera.com

Principal Investigator

Clinical Team
STUDY_DIRECTOR
Deciphera Pharmaceuticals, LLC

Study Locations (Sites)

NEXT Oncology
San Antonio, Texas, 78229
United States

Collaborators and Investigators

Sponsor: Deciphera Pharmaceuticals, LLC

  • Clinical Team, STUDY_DIRECTOR, Deciphera Pharmaceuticals, LLC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08
Study Completion Date2029-02

Study Record Updates

Study Start Date2025-08
Study Completion Date2029-02

Terms related to this study

Keywords Provided by Researchers

  • Advanced malignancies

Additional Relevant MeSH Terms

  • Renal Cell Carcinoma
  • Urothelial Carcinoma
  • Castration-resistant Prostate Cancer