RECRUITING

Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with bleeding and potential symptoms of dysphoria (a feeling of discomfort or distress). Topical estrogen cream is sometimes used if patients have increased risk of bleeding with surgery but is not currently utilized in a consistent way. This study aims to answer the question of whether this is a helpful treatment and should be included in standard postoperative care.

Official Title

Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

Quick Facts

Study Start:2025-05-01
Study Completion:2026-12-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06969326

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Gender diverse/transgender men
  2. 2. Age 18 or older
  3. 3. Have been on testosterone for at least 6 months with plan to undergo gender-affirming hysterectomy and are willing to be randomized to the use of topical estrogen postoperatively.
  4. 4. Have stable physical and mental health
  5. 5. No contraindications to estrogen therapy
  6. 6. Must be proficient in English or Spanish
  7. 7. Must have access to a device to receive text messages for study follow up
  8. 8. Must agree to allow their medical data to be used for research purposes
  1. 1. Under age 18
  2. 2. Have not been on testosterone for at least 6 months prior to planned hysterectomy
  3. 3. Known allergy to topical estrogen

Contacts and Locations

Study Contact

Beth Cronin, MD
CONTACT
401-274-1122
bcronin@wihri.org

Study Locations (Sites)

Women & Infants Hospital
Providence, Rhode Island, 02905
United States

Collaborators and Investigators

Sponsor: Women and Infants Hospital of Rhode Island

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-01
Study Completion Date2026-12-01

Study Record Updates

Study Start Date2025-05-01
Study Completion Date2026-12-01

Terms related to this study

Keywords Provided by Researchers

  • gender dysphoria
  • gender affirmation
  • hysterectomy

Additional Relevant MeSH Terms

  • Postoperative Bleeding
  • Gender Dysphoria
  • Hysterectomy