Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

Description

The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with bleeding and potential symptoms of dysphoria (a feeling of discomfort or distress). Topical estrogen cream is sometimes used if patients have increased risk of bleeding with surgery but is not currently utilized in a consistent way. This study aims to answer the question of whether this is a helpful treatment and should be included in standard postoperative care.

Conditions

Postoperative Bleeding, Gender Dysphoria, Hysterectomy

Study Overview

Study Details

Study overview

The purpose of this study is to determine if applying a single dose of topical estrogen cream in the operating room at the end of your hysterectomy (removal of uterus and cervix) improves the postoperative experience with bleeding and potential symptoms of dysphoria (a feeling of discomfort or distress). Topical estrogen cream is sometimes used if patients have increased risk of bleeding with surgery but is not currently utilized in a consistent way. This study aims to answer the question of whether this is a helpful treatment and should be included in standard postoperative care.

Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

Condition
Postoperative Bleeding
Intervention / Treatment

-

Contacts and Locations

Providence

Women & Infants Hospital, Providence, Rhode Island, United States, 02905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Gender diverse/transgender men
  • 2. Age 18 or older
  • 3. Have been on testosterone for at least 6 months with plan to undergo gender-affirming hysterectomy and are willing to be randomized to the use of topical estrogen postoperatively.
  • 4. Have stable physical and mental health
  • 5. No contraindications to estrogen therapy
  • 6. Must be proficient in English or Spanish
  • 7. Must have access to a device to receive text messages for study follow up
  • 8. Must agree to allow their medical data to be used for research purposes
  • 1. Under age 18
  • 2. Have not been on testosterone for at least 6 months prior to planned hysterectomy
  • 3. Known allergy to topical estrogen

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Women and Infants Hospital of Rhode Island,

Study Record Dates

2026-12-01