PET/MRI/EEG Imaging Study in Epilepsy

Description

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Conditions

Epilepsy

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Study Overview

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Study Details

Study overview

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

PET/MRI/EEG Imaging Study in Epilepsy

Condition
Epilepsy
Intervention / Treatment

-

Contacts and Locations

Charlestown

Athinoula A. Martinos Center, Charlestown, Massachusetts, United States, 02129

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 or older
  • * Diagnosed with epilepsy with abnormal interictal EEG
  • * Contraindications to PET, MRI, or EEG imaging
  • * History of severe brain disease such as stroke and head trauma
  • * History of brain surgery
  • * History of type I or II diabetes mellitus
  • * Fasting plasma glucose level \>200 mg/dL
  • * Employed under direct supervision of the PI conducting the research
  • * Current use of drugs that modulate brain function
  • * Current or past history of major medical, neurological, or psychiatric conditions

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Massachusetts General Hospital,

Ciprian Catana, MD, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

2025-11-30