RECRUITING

PET/MRI/EEG Imaging Study in Epilepsy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography \[FDG-PET\], and blood flow, measured by functional magnetic resonance imaging \[fMRI\]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography \[EEG\]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.

Official Title

Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging

Quick Facts

Study Start:2023-09-21
Study Completion:2025-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06974305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 or older
  2. * Diagnosed with epilepsy with abnormal interictal EEG
  1. * Contraindications to PET, MRI, or EEG imaging
  2. * History of severe brain disease such as stroke and head trauma
  3. * History of brain surgery
  4. * History of type I or II diabetes mellitus
  5. * Fasting plasma glucose level \>200 mg/dL
  6. * Employed under direct supervision of the PI conducting the research
  7. * Current use of drugs that modulate brain function
  8. * Current or past history of major medical, neurological, or psychiatric conditions

Contacts and Locations

Study Contact

Magdelena S Allen, BA
CONTACT
617-724-9232
mallen27@mgh.harvard.edu

Principal Investigator

Ciprian Catana, MD, PhD
PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital

Study Locations (Sites)

Athinoula A. Martinos Center
Charlestown, Massachusetts, 02129
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Ciprian Catana, MD, PhD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-21
Study Completion Date2025-11-30

Study Record Updates

Study Start Date2023-09-21
Study Completion Date2025-11-30

Terms related to this study

Keywords Provided by Researchers

  • Functional PET
  • FDG-PET
  • Functional MRI
  • EEG
  • Epilepsy
  • Neuroimaging
  • Multimodal imaging

Additional Relevant MeSH Terms

  • Epilepsy