RECRUITING

Matching Treatments to Cognitive Deficits in Offenders With Substance Use Disorders

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to investigate the effect of two types of cognitive remediation training on real-world behavioral outcomes including substance use, institutional adjustment, and recidivism following release from prison. Each training type is designed to target one of two subtypes of antisocial criminal offenders, who are characterized by either: 1) Attention to context-based deficits, or 2) Affective cognitive control-based deficits. The main questions it aims to answer are: Does matching deficit type with targeted cognitive training improve outcomes (relative to mismatched training)? What are the functional brain mechanisms that underlie treatment change? Participants will: Be assigned to cognitive training that either does or does not match their deficit type. Complete six one-hour sessions of cognitive skills training. Complete pre and post-training behavioral tasks assessing self-regulation deficits. Complete structural MRI scans and functional MRI scans assessing cognitive control. Complete post-treatment follow-up assessments evaluating self-regulation, adjustment, and stressful life events, substance use and recidivism.

Official Title

Matching Treatments to Cognitive Deficits in Offenders With Substance Use Disorders

Quick Facts

Study Start:2025-03-18
Study Completion:2029-05-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06981351

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 55 Years
Sexes Eligible for Study:MALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Currently incarcerated
  2. * No uncorrectable auditory or visual deficits
  3. * Able to speak and/or understand English
  4. * 5th grade reading level or higher
  5. * IQ score = 80 or above
  6. * Lifetime history of substance use disorder based on DSM criteria
  7. * No history of dementia or other cognitive disability
  8. * No indication of current psychotic disorder
  9. * No major medical illness or CNS disease
  10. * Scores from the Psychopathy Checklist-Revised (PCL-R) meet criteria for one of the designated treatment groups
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Carla Harenski
CONTACT
505-272-5028
charenski@mrn.org

Study Locations (Sites)

Mind Research Network/Lovelace Biomedical Research Institute
Albuquerque, New Mexico, 87106
United States

Collaborators and Investigators

Sponsor: The Mind Research Network

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-18
Study Completion Date2029-05-31

Study Record Updates

Study Start Date2025-03-18
Study Completion Date2029-05-31

Terms related to this study

Keywords Provided by Researchers

  • Cognitive skills training
  • Attention to Context
  • Affective Cognitive Control

Additional Relevant MeSH Terms

  • Antisocial Behavior