RECRUITING

Vascular Function and Oxidative Stress in Emergency Medical Responders

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs). The main questions it aims to answer are: 1. Does an overnight shift work in emergency medical technicians reduce blood vessel function and increase oxidative stress? 2. Can supplementing with antioxidants help reduce the negative effects of night shift work in emergency medical technicians? Researchers will compare antioxidants to a placebo (a look-alike substance that contains no drug) to see if antioxidants work in reducing the negative effects of night shift work in emergency medical technicians. Participants will: 1. Report to the lab two separate times following an overnight shift to assess blood vessel functioning and oxidative stress 3. Take an antioxidant supplement or placebo during each night of shift work.

Official Title

Vascular Function and Oxidative Stress in Emergency Medical Responders

Quick Facts

Study Start:2025-05-14
Study Completion:2025-10
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06985394

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:20 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Body mass index between 18.5 and \<35 kg/m²
  2. * Seated resting systolic blood pressure \< 140 mmHg, and seated resting diastolic blood pressure \< 90 mmHg
  3. * Participant must be an active first responder that works shift work schedules. e.g., emergency medical responders, basic life support emergency medical technicians (i.e., BLS EMT), advanced life support emergency medical technicians (A-EMT), and paramedics
  4. * Participant must have been working shift work for at least 1 year
  5. * Participant must work at least 4 night shifts per month
  1. * Participant is unwilling or unable to give consent
  2. * Participant has been diagnosed with any chronic disease (a history of high blood pressure, heart disease, diabetes, cancer, kidney disease)
  3. * Participant has been diagnosed with a sleep disorder (e.g., insomnia, restless leg syndrome, sleep apnea)
  4. * Participant is currently taking melatonin or other sleep aids (e.g., Ambien, sedatives, etc.), or any supplements/medications known to alter sleep patterns. Participants using melatonin must undergo a minimum 72-hour washout period prior to study participation to ensure baseline sleep patterns are not affected\[15, 16\]
  5. * Resting blood pressure \>140/90 mmHg
  6. * Body mass index \<18.5 or \>35 kg/m2
  7. * Currently pregnant or breast feeding (women only)
  8. * Currently use tobacco or nicotine products (≥1 cigarette, cigar, e-cigarette, vape, or any other nicotine-containing product in the last month), including smokeless tobacco (e.g., chewing tobacco, snuff, dip, snus), nicotine lozenges or gum, heated tobacco products, and any illicit drugs

Contacts and Locations

Study Contact

Alexs Matias, MS
CONTACT
914-523-1953
amatias@udel.edu

Study Locations (Sites)

University of Delaware
Newark, Delaware, 19713
United States

Collaborators and Investigators

Sponsor: University of Delaware

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-14
Study Completion Date2025-10

Study Record Updates

Study Start Date2025-05-14
Study Completion Date2025-10

Terms related to this study

Keywords Provided by Researchers

  • EMT
  • First Responder
  • Oxidative Stress
  • Paramedic
  • Emergency Medical Technician

Additional Relevant MeSH Terms

  • Cardiovascular Function in EMTs