RECRUITING

The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are: Does the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases. Participants will: Complete resistance exercise protocols across three different menstrual cycle phases. Provide blood samples to assess immune cell activation and muscle damage markers. Track sleep, mood, and recovery with questionnaires and wear an accelerometer.

Official Title

The Impact of the Menstrual Cycle on Innate Immune Cell Activation, Recruitment, and Adhesion Dynamics During Recovery From Damaging Resistance Exercise: Role of Neutrophils and Systemic Chemokines.

Quick Facts

Study Start:2024-08-16
Study Completion:2025-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06985420

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Women between the ages of 18 and 40.
  2. * Must weigh at least 110 pounds.
  3. * Healthy as determined by medical history, physical activity readiness, and menstrual cycle questionnaires.
  4. * Actively resistance training for at least 6 months (minimum of 3 resistance training sessions per week, with at least one lower body session).
  5. * Pre-menopausal and have a regular menstrual cycle (eumenorrheic), with a clear start of menses (early follicular phase).
  6. * Not currently pregnant or planning to become pregnant during the study.
  7. * Have not used hormonal birth control or intrauterine devices in the past 3 months (or three full menstrual cycles).
  8. * Able to recall approximate start dates of their last 6 menstrual cycles.
  9. * Willing to follow study instructions, including avoiding exercise, alcohol, and caffeine before testing visits.
  10. * Free from previous or current lower body injuries that could limit performance.
  11. * Not regularly taking any medications that could interfere with the study.
  12. * Determined to have a high likelihood of successful blood draws by a certified phlebotomist.
  1. * Do not give consent to participate.
  2. * Have been determined unfit to participate based on medical or activity history (using health questionnaires).
  3. * Currently take prescription or over-the-counter medication that could affect the study results.
  4. * Have a chronic illness requiring medical care.
  5. * Not currently resistance-trained (don't meet the exercise requirement).
  6. * Pregnant or planning to become pregnant during the study.
  7. * Do not have regular periods or have been diagnosed as amenorrhoeic (absence of menstruation).
  8. * Currently taking any performance-enhancing drugs.
  9. * Currently using hormonal birth control or intrauterine devices (IUDs), or have used them in the past three months (or three full menstrual cycles).
  10. * Determined unlikely to have a successful blood draw by a trained phlebotomist.
  11. * Weigh less than 110 pounds.

Contacts and Locations

Study Contact

Jessica M Moon
CONTACT
407-823-0623
jessica.moon@ucf.edu

Study Locations (Sites)

University of Central Florida
Orlando, Florida, 32816
United States

Collaborators and Investigators

Sponsor: University of Central Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-16
Study Completion Date2025-05

Study Record Updates

Study Start Date2024-08-16
Study Completion Date2025-05

Terms related to this study

Additional Relevant MeSH Terms

  • Healthy Women
  • Menstruation
  • Resistance Exercise