Impact of Semaglutide on Tobacco Use and Related Health Behaviors

Eligibility Criteria

• 1. Severe psychiatric disturbance precluding successful completion of the study, defined as
• 2. personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia syndrome, and personal history of pancreatitis, type I or type II diabetes, diabetic retinopathy, or gastroparesis;
• 3. current use of nicotine replacement therapy or other quit smoking medication;
• 4. history of bariatric surgery;
• 5. Current or past 6-month use of a GLP-1 agonist or any other weight-lowering/anti-obesity or glucose-lowering medications. These include (but are not limited to: sulfonylurea, insulin, metformin, thiazolidinediones (TZD), dipeptidyl peptidase-4 (DPP-IV) inhibitors, sodium-glucose cotransporter-2 (SGLT-2) inhibitors, or GLP-1 analogs.
• 6. Clinical labs out of range/unacceptable:
• 1. creatinine ≥ 2 mg/dL, eGFR ≤ 60 mL/min/1.73 m2,
• 2. triglycerides\> 500 mg/dl,
• 3. ALP \> 4x the upper normal limit,
• 4. abnormal blood lipase levels,
• 5. other substantially abnormal clinical lab values as determined by the Study Practitioner
• 6. A1C 6.5% or higher
• 7. Glucose \>126 mL fasting or \>200mg/dL random
• 8. Alanine aminotransferase (ALT) \>3x upper normal limit
• 7. History of significant gastrointestinal disorder, including inflammatory bowel disease or gastrointestinal malignancy (celiac disease is accepted if in remission), diverticular disease, severe gastroparesis, diagnosis of mega-rectum or colon, congenital anorectal malformation, or clinically significant rectocele, intestinal or colonic obstruction, or suspected intestinal obstruction, intestinal resection (with an exception for appendectomy, cholecystectomy and inguinal hernia repair), pancreatitis, active biliary disease
• 8. Any other reason or clinical condition that the investigators judge would interfere with study participation and/or be unsafe for a possible subject.
• 9. Known or suspected allergy to semaglutide, any of the product components, or any other GLP-1 analogue.