RECRUITING

MEP Up-conditioning to Target Corticospinal Plasticity

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding muscle response (wrist extensor). Investigators will assess the impact of the brain stimulation training on 1) the brain-to-spinal cord-to-muscle connection and 2) motor functions of the arm and hand. Also, brain and spine magnetic resonance imaging will be collected before and after the training. The imaging measurements will tell investigators about how spinal damage, brain function, and brain structure relate to motor presentation and the response to the training.

Official Title

Operant Conditioning of the Wrist Extensor Motor Evoked Potential to Target Corticospinal Plasticity and Upper Limb Motor Recovery After Cervical Spinal Cord Injury

Quick Facts

Study Start:2025-05-27
Study Completion:2027-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06989905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult (≥18 yrs old)
  2. * A history of injury to spinal cord at or above C6
  3. * \>6 months post SCI
  4. * Weak wrist extension at least unilaterally
  5. * Expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted.
  1. * Motoneuron injury
  2. * Medically unstable condition
  3. * Cognitive impairment
  4. * A history of epileptic seizures
  5. * Metal implants in the cranium
  6. * Implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)
  7. * Extensive use of functional electrical stimulation to the arm on a daily basis
  8. * Pregnancy (due to changes in posture and potential medical instability)
  9. * Contraindications to MRI
  10. * No measurable MEP elicited in the ECR
  11. * Unable to produce any voluntary ECR EMG activity

Contacts and Locations

Study Contact

Recruitment Contact
CONTACT
843-792-6313
stecb@musc.edu

Principal Investigator

Allison Lewis, DPT, PhD
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Allison Lewis, DPT, PhD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-27
Study Completion Date2027-03-31

Study Record Updates

Study Start Date2025-05-27
Study Completion Date2027-03-31

Terms related to this study

Keywords Provided by Researchers

  • Central Nervous System
  • Nervous System
  • Rehabilitation Studies
  • Spinal Cord
  • spinal cord injury
  • upper extremity
  • upper limb
  • motor impairment
  • tetraplegia
  • quadriplegia

Additional Relevant MeSH Terms

  • Spinal Cord Injury
  • Tetraplegia/Tetraparesis