RECRUITING

Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs. The purpose of this study is to compare the effects of 2 methods, pressure support ventilation (PSV) versus automatic tube compensation (ATC), on successful extubation for critically ill adult patients who received mechanical ventilation for over 24 hours.

Official Title

Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Critically Ill Adults: A Cluster-Randomized, Cluster-Crossover Trial

Quick Facts

Study Start:2025-06-01
Study Completion:2027-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07005505

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Admitted to intensive care unit (ICU)
  2. * Age 18 years or older
  3. * Requiring invasive mechanical ventilation for at least 24 hours
  4. * Pass spontaneous breathing trial screen criteria
  1. * Clinical decision made not to proceed with extubation regardless of spontaneous breathing trial (SBT) results
  2. * Do not intubate (DNI) order
  3. * Presence of tracheostomy
  4. * Pregnancy
  5. * Known prisoner
  6. * Immediate need for extubation, self-extubation, or unplanned extubation that precludes safe performance of study procedures
  7. * Enrolled in another clinical trial that impacts ventilator weaning or liberation

Contacts and Locations

Study Contact

Jie Li, PhD
CONTACT
312-563-4643
Jie_Li@rush.edu
Lauren Harnois, MSc
CONTACT
Lauren_J_Harnois@rush.edu

Study Locations (Sites)

Rush University Medical Center
Chicago, Illinois, 60612
United States

Collaborators and Investigators

Sponsor: Rush University Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-01
Study Completion Date2027-08

Study Record Updates

Study Start Date2025-06-01
Study Completion Date2027-08

Terms related to this study

Keywords Provided by Researchers

  • Ventilator liberation
  • Spontaneous breathing trial

Additional Relevant MeSH Terms

  • Spontaneous Breathing Trial in ICU