RECRUITING

Hair Biomarkers Study

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Conditions

HealthyToxic stressInfantsCortisolOxytocinEarly child development

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Young children aged 0-4 years may be exposed to adverse childhood experiences (ACEs) and/or early life adversity (ELA), which are linked with worse physical and mental health across their lifespan. On the other hand, positive childhood experiences (PCEs) can build resilience and prevent or protect against these detrimental outcomes. Data analyses will assess the interactions of ACEs, PCEs, parenting, and poverty on the early social psychology of childhood and develop objective measures for altered stress regulation using hair cortisol as a chronic stress biomarker.

Official Title

Hair Biomarkers Study

Quick Facts

Study Start:2024-11-18
Study Completion:2029-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07011082

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Months to 24 Months
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. 1. Normal, healthy children aged 6 months to 24 months and their mothers (or father, if mother is not able to participate).
  2. 2. Living in Santa Clara County, San Mateo County, or Alameda County in Northern California.
  3. 3. Willing to give their home address (in order to receive the study kits at home).
  4. 4. Committed to regular follow-up at 6-month intervals for the full study duration of 2 years.
  1. 1. Children with tinea capitis, alopecia areata, scalp eczema, dermatitis, or other scalp conditions.
  2. 2. Children exposed to systemic steroid therapy for any diagnosis in the 3 months prior to study entry.
  3. 3. Children receiving any other prescription drugs that alter HPA axis function or cortisol release, if the period of exposure is 2 weeks or longer within the 3 months prior to study entry.
  4. 4. Children with chronic medical conditions such as cystic fibrosis, sickle cell disease, asthma, eczema, or other chronic conditions.
  5. 5. Children with known developmental delay, Trisomy-21 and other chromosomal anomalies, seizure disorders, chronic pain, cerebral palsy, or other disabilities.
  6. 6. Children whose hair has received chemical exposures (e.g., dying, bleaching, chemical straightening, perming) in the 90 days prior to study entry or for 90 days before each follow-up appointment during the 2-year study period.

Contacts and Locations

Study Contact

Kanwaljeet J.S. Anand, MBBS, DPhil
CONTACT
(650) 498-6313
anandam@stanford.edu
Cynthia R Rovnaghi, PhD
CONTACT
‭+1 (501) 606-1129‬
crovnagh@stanford.edu

Study Locations (Sites)

Stanford University
Palo Alto, California, 94304
United States

Collaborators and Investigators

Sponsor: Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-18
Study Completion Date2029-12

Study Record Updates

Study Start Date2024-11-18
Study Completion Date2029-12

Terms related to this study

Keywords Provided by Researchers

  • Toxic stress
  • Infants
  • Cortisol
  • Oxytocin
  • Early child development

Additional Relevant MeSH Terms

  • Healthy