RECRUITING

Ultralow Dose PET Imaging of 18F-Florbetapir, 18F-Flutemetamol

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to evaluate an investigational ultralow dose PET imaging technique for Alzheimer's disease, mild cognitive impairment, other forms of dementia detection and monitoring. The main question it aims to answer is: Can the investigators optimize the timing, scan duration, and image reconstruction to reduce the radiation dose 10-100 fold of the current clinical standard? Participants will be injected with a radioactive tracer called 18F-Florbetapir or 18F-Flutemetamol and be imaged on a new type of high-sensitivity PET scanner for up to 3 hours

Official Title

Evaluation of Ultralow Dose PET Imaging for Detecting Amyloid Tracer Uptake

Quick Facts

Study Start:2025-05-20
Study Completion:2030-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07012993

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 120 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Age ≥18 years.
  2. 2. Ability to provide informed consent and comply with study procedures.
  3. 3. For female participants:
  4. * Must not be pregnant or breastfeeding.
  5. * Negative pregnancy test required for women of childbearing potential.
  1. 1. Participants who have exceeded NRC regulation for annual radiation exposure from prior research-related scans, including this study (50 mSv total).
  2. 2. More than four prior enrollments in this study.
  3. 3. Participants with severe claustrophobia, chronic pain, or musculoskeletal conditions that prevent completion of the PET scan
  4. 4. Pregnant or breastfeeding individuals (negative pregnancy test required)
  5. 5. Inability to provide informed consent
  6. 6. Any condition that, in the investigator's judgment, may compromise participant safety or study integrity.

Contacts and Locations

Study Contact

Barbara Blanchfield
CONTACT
973-255-4955
bblanchfield@nii.org

Study Locations (Sites)

Nuclear Imaging Institute
Englewood, New Jersey, 07631
United States

Collaborators and Investigators

Sponsor: Akiva Mintz

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-20
Study Completion Date2030-06-30

Study Record Updates

Study Start Date2025-05-20
Study Completion Date2030-06-30

Terms related to this study

Additional Relevant MeSH Terms

  • Healthy Volunteer
  • Alzheimer's Disease, Mild Cognitive Impairment, Other Forms of Dementia