RECRUITING

Liraglutide Treatment in Patients With Maturity-onset Diabetes of the Young (MODY)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The reason for this research study is to better understand the use of liraglutide, a commonly prescribed Type 2 diabetes medication, in patients with a diagnosis of maturity-onset diabetes of the young (MODY). The investigators are interested in better understanding the way that this drug affects the metabolism and hormone levels of a person with MODY. Many people with MODY report having gastrointestinal (GI) issues such as an upset stomach. Investigators also interested in finding out if this drug will help with GI issues. If liraglutide does help with this symptom of MODY, the investigators want to know why this happens. If this drug is effective for participants, the investigators will use participants cells to make human induced pluripotent stem cell (iPSC). This means that the investigators will use participant cells to create what are called stem cells, which are cells in the body that are able to be told what their job is. Investigators will use these cells to see what happens in gastrointestinal (GI) tract.

Official Title

Investigating Enteroendocrine Dysfunction, Metabolism, and Response to Liraglutide in Patients With Maturity-onset Diabetes of the Young (MODY)

Quick Facts

Study Start:2025-05-08
Study Completion:2027-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07029009

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:10 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of MODY via genetic testing
  2. * HgbA1c \>6.5%
  1. * History of anaphylaxis to GLP-1 receptor agonists
  2. * Already taking GLP-1 receptor agonists
  3. * on medications within the stimulant class
  4. * have had bariatric surgery
  5. * personal or family history of cancer, especially medullary thyroid cancer
  6. * personal history of pancreatitis or pathogenic variants associated with increased risk of pancreatitis
  7. * known active kidney disease
  8. * severe hypoglycemia (glucose \< 50 mg/dL) within 3 months of study enrollment
  9. * HbA1c \> 10.0%
  10. * episode of diabetic ketoacidosis (DKA) in the past 3 months
  11. * are currently pregnant
  12. * BMI \< 18.5 kg/m2 and pediatric patients with BMI \< 5th percentile

Contacts and Locations

Study Contact

Mansa Krishnamurthy, M.D.
CONTACT
513-636-4744
mansa.krishnamurthy@cchmc.org

Principal Investigator

Mansa Krishnamurthy, M.D.
PRINCIPAL_INVESTIGATOR
Children's Hospital Medical Center, Cincinnati

Study Locations (Sites)

Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229
United States

Collaborators and Investigators

Sponsor: Mansa

  • Mansa Krishnamurthy, M.D., PRINCIPAL_INVESTIGATOR, Children's Hospital Medical Center, Cincinnati

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-08
Study Completion Date2027-01

Study Record Updates

Study Start Date2025-05-08
Study Completion Date2027-01

Terms related to this study

Additional Relevant MeSH Terms

  • Maturity Onset Diabetes of the Young