RECRUITING

Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.

Official Title

A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

Quick Facts

Study Start:2025-07-29
Study Completion:2030-09-29
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07037433

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:45 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Amgen Call Center
CONTACT
866-572-6436
medinfo@amgen.com

Principal Investigator

MD
STUDY_DIRECTOR
Amgen

Study Locations (Sites)

Heart Center Research LLC
Huntsville, Alabama, 35801
United States
Mobile Heart Specialists PC
Mobile, Alabama, 36608
United States
Velocity Clinical Research- Los Angeles
Los Angeles, California, 90017
United States
Velocity Clinical Research - Boise
Meridian, Idaho, 83642
United States
MD Medical Research
Oxon Hill, Maryland, 20745
United States
Velocity Clinical Research - Binghamton
Binghamton, New York, 13905
United States
Velocity Clinical Research - Cleveland
Beachwood, Ohio, 44122
United States
Velocity Clinical Research - Auburn
Cincinnati, Ohio, 45219
United States
Heritage Valley Multispecialty Group Inc
Beaver, Pennsylvania, 15009
United States
Velocity Clinical Research - Providence
East Greenwich, Rhode Island, 02818
United States
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, 37388
United States
Velocity Clinical Research - Salt Lake City
West Jordan, Utah, 84088
United States

Collaborators and Investigators

Sponsor: Amgen

  • MD, STUDY_DIRECTOR, Amgen

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-29
Study Completion Date2030-09-29

Study Record Updates

Study Start Date2025-07-29
Study Completion Date2030-09-29

Terms related to this study

Keywords Provided by Researchers

  • Atherosclerotic Cardiovascular Disease
  • Overweight
  • Obesity
  • Maridebart cafraglutide
  • AMG 133
  • MariTide

Additional Relevant MeSH Terms

  • Atherosclerotic Cardiovascular Disease
  • Overweight
  • Obesity