RECRUITING

Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.

Official Title

A Phase 1/2, First-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors

Quick Facts

Study Start:2025-06-19
Study Completion:2030-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07038343

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Medical Information
CONTACT
(858) 239-2944
ClinicalTrials@avenzotx.com

Study Locations (Sites)

Avenzo Therapeutics Recruiting Site
Dallas, Texas, 75039
United States
Avenzo Therapeutics Recruiting Site
Houston, Texas, 77054
United States
Avenzo Therapeutics Recruiting Site
San Antonio, Texas, 78229
United States
Avenzo Therapeutics Recruiting Site
Fairfax, Virginia, 22031
United States

Collaborators and Investigators

Sponsor: Avenzo Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-19
Study Completion Date2030-12

Study Record Updates

Study Start Date2025-06-19
Study Completion Date2030-12

Terms related to this study

Keywords Provided by Researchers

  • Solid Tumors
  • Metastatic
  • Locally Advanced
  • Lung Cancer
  • Epithelial Solid Tumors

Additional Relevant MeSH Terms

  • Solid Tumor Cancer
  • Locally Advanced
  • Metastatic Solid Tumors
  • Lung Cancers
  • Epithelial Tumor