RECRUITING

Physical Capacity Building for Chronic Stroke

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Cardiac rehabilitation is the standard-of-care treatment option for patients with cardiovascular disease and has been shown to improve many aspects critical to patient recovery. Investigators believe that individuals who have had a stroke need to be treated similarly. Investigators will study the effects of a comprehensive modified cardiac rehabilitation program to determine if it can improve some of the physical and psychosocial problems common in survivors of stroke with and without depression.

Official Title

Modified Cardiac Rehabilitation to Enhance Post-Stroke Physical and Psychosocial Function: Does Depression Limit the Response?

Quick Facts

Study Start:2025-08-05
Study Completion:2029-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07039305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 70 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-70
  2. * A diagnosis of stroke at least 6 months prior
  3. * Residual paresis in the lower extremity (Fugl-Meyer lower extremity \[LE\] motor score \<34)
  4. * Ability to walk without assistance and without an AFO during testing and training at speeds ranging from 0.2-1.0 m/s
  5. * Ability to follow instructions, complete cognitive testing and to communicate exertion, pain and distress
  6. * No antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication)
  7. * HDRS17 question #3 and PHQ-9 question #9 regarding suicide ≤ 2
  8. * Provision of informed consent.
  1. * Unable to ambulate at least 150 feet or experienced intermittent claudication while walking
  2. * Unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's
  3. * Dementia
  4. * Life expectancy \<1 yr
  5. * History of DVT or pulmonary embolism within 6 months
  6. * Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
  7. * Severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest
  8. * Attempt of suicide in the last 2 years or suicidal risk assessed by depression screening
  9. * Current enrollment in a rehabilitation trial to enhance motor, cognitive and or psychosocial recovery
  10. * Severe cognitive impairment (MoCA score ≤15)
  11. * Moderate to severe neglect that precludes cognitive testing
  12. * Electronic or metallic implants
  13. * History of seizures
  14. * Women of child bearing potential

Contacts and Locations

Study Contact

Ryan E Ross, Ph.D.
CONTACT
843-792-3477
rossre@musc.edu

Principal Investigator

Ryan Ross
PRINCIPAL_INVESTIGATOR
Medical University of South Carolina

Study Locations (Sites)

Medical University of South Carolina
Charleston, South Carolina, 29425
United States

Collaborators and Investigators

Sponsor: Medical University of South Carolina

  • Ryan Ross, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-05
Study Completion Date2029-08

Study Record Updates

Study Start Date2025-08-05
Study Completion Date2029-08

Terms related to this study

Keywords Provided by Researchers

  • Depression
  • Exercise
  • Stroke
  • Stroke Recovery

Additional Relevant MeSH Terms

  • Stroke
  • Post-stroke Depression