RECRUITING

Evaluation of Ketamine/Midazolam Deep Sedation vs. Fentanyl/Midazolam Moderate Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Official Title

Prospective Single-Blinded Randomized Study of Ketamine/Midazolam Deep Sedation vs. Fentanyl/Midazolam Moderate Sedation for Image-Guided Percutaneous Procedures in Interventional Radiology

Quick Facts

Study Start:2025-03-07
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07040163

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Planned to undergo image-guided bone biopsy, lung biopsy, or percutaneous drainage
  2. * Eligible to receive ketamine or fentanyl sedation
  3. * Any sex/gender, any race
  4. * Aged 18-89
  1. * Pregnant/lactating
  2. * Incarceration
  3. * Currently taking an opioid agonist/antagonist
  4. * Food consumed in past 6-8 hours
  5. * Allergies to drugs used in the study
  6. * Lacks mental capacity for reporting pain scores
  7. * Hypotension or respiratory failure precluding fentanyl sedation
  8. * Uncontrolled hypertension precluding ketamine sedation
  9. * Condition for which hypertension would be a concern
  10. * Schizophrenia

Contacts and Locations

Study Contact

Amy R Deipolyi, M.D., Ph.D.
CONTACT
304-388-0193
amy.deipolyi@vandaliahealth.org
Adam M Belcher, Ph.D.
CONTACT
304-388-9920
adam.belcher@vandaliahealth.org

Principal Investigator

Amy R Deipolyi, M.D., Ph.D.
PRINCIPAL_INVESTIGATOR
CAMC Department of Interventional Radiology

Study Locations (Sites)

CAMC Memorial
Charleston, West Virginia, 25304
United States

Collaborators and Investigators

Sponsor: CAMC Health System

  • Amy R Deipolyi, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, CAMC Department of Interventional Radiology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-07
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2025-03-07
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • ketamine
  • interventional radiology
  • fentanyl
  • sedation

Additional Relevant MeSH Terms

  • Sedation
  • Interventional Radiology
  • Biopsy
  • Drainage Procedure