RECRUITING

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to learn how exercise timing affects blood pressure in adults with elevated or high blood pressure. Exercise can influence the body's natural 24-hour rhythms, including blood pressure patterns. A single exercise session can lower blood pressure for up to 24 hours, but it is not fully understood how the time-of-day for exercise affects this response. The main question this study aims to answer is: • When the same participant exercises at different times of day (morning, afternoon, or evening), how does this affect the participant's blood pressure over the next 24 hours? Participants will: * Undergo an in-lab assessment of individual biological rhythm that will indicate the clock-time for an individual's biological night * Complete 3 supervised treadmill exercise sessions * 1 in the biological morning (biological night + 10 hours) * 1 in the biological afternoon (biological night + 15 hours) * 1 in the biological evening (biological night + 20 hours) * Complete a 24-hour blood pressure assessment before and after each exercise session

Official Title

Examining the Circadian Timing Effects of the Hypotensive Response to Exercise

Quick Facts

Study Start:2025-07-22
Study Completion:2026-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07049783

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 39 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * 18-39 Years old
  2. * Resting blood pressure greater than or equal to 120/80 mmHg or less than 140/90 mmHg
  1. * Diagnosis or history of chronic or autoimmune disease (i.e., cardiovascular, metabolic, renal, endocrine, cancer)
  2. * Diagnosis or history of sleep disorder (i.e., obstructive sleep apnea, insomnia, restless leg syndrome)
  3. * Alcohol or drug dependence
  4. * Elevated risk for sleep disorders
  5. * Elevated risk for clinical depression
  6. * Normotensive (blood pressure less than 120/80 mmHg) or stage 2+ hypertension (blood pressure greater than or equal to 140/90 mmHg)
  7. * Body mass index less than 18.5 or greater than 35 kg/m2
  8. * Self-reported use of sleep medications/supplements (e.g., melatonin)
  9. * Self-reported use of medications influencing vascular physiology (e.g., antihypertensive medications, weight loss medications)
  10. * Highly physically active (greater than or equal to 300 minutes moderate-to-vigorous physical activity per week)
  11. * Currently pregnant or breastfeeding
  12. * Current tobacco use (greater than or equal to 1 cigarette in the past month)
  13. * Nighttime or rotating shift work within the last 3 months
  14. * Contraindications to aerobic exercise

Contacts and Locations

Study Contact

Freda Patterson, PhD
CONTACT
302-831-6588
fredap@udel.edu
Thomas Keiser
CONTACT
302-831-6588
tkeiser@udel.edu

Study Locations (Sites)

University of Delaware
Newark, Delaware, 19713
United States

Collaborators and Investigators

Sponsor: Freda Patterson

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-22
Study Completion Date2026-09

Study Record Updates

Study Start Date2025-07-22
Study Completion Date2026-09

Terms related to this study

Keywords Provided by Researchers

  • Young adults
  • Hypertension
  • Post-exercise hypotension
  • Circadian rhythm

Additional Relevant MeSH Terms

  • Young Adults
  • Hypertension
  • Post-Exercise Hypotension
  • Circadian Rhythm