RECRUITING

Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation

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Conditions

Obsessive-Compulsive DisorderAdolescenttranscranial magnetic stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a pilot study to examine the tolerability, safety and early efficacy of two forms of transcranial magnetic stimulation (TMS) for treating adolescents with Obsessive Compulsive Disorder (OCD) who have experienced limited improvements with usual treatments for OCD in adolescents. The project's primary goal is to examine whether adolescents can complete 3 consecutive weeks of TMS administered 5 days per week, and to describe the type of and how common individual side effects with TMS occur in adolescents with OCD. Participants will: * visit the clinic every weekday for 3 weeks (15 days) to receive TMS treatments * have a brain MRI scan before TMS treatments begins and after finishing all TMS * complete questionnaires and report changes in behavior and physical symptoms

Official Title

Treating Adolescent Obsessive Compulsive Disorder With Transcranial Magnetic Stimulation

Quick Facts

Study Start:2025-06-01
Study Completion:2027-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07065669

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:13 Years to 17 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. 1. outpatients
  2. 2. ages 13 - 17 years
  3. 3. meets current DSM-5 criteria for Obsessive Compulsive Disorder with screening CY-BOCS II score \> 16 (moderate to severe).
  4. 4. stable on chronic psychotropic medications and/or therapy for 8 weeks prior to the study and agreeable to continue throughout the study without changes.
  5. 5. participants may continue to take medications and record daily usage throughout the study.
  6. 6. capacity to provide informed assent and parent or legal guardian able to provide consent.
  7. 7. ability to tolerate clinical study procedures.
  8. 8. successfully complete the screening forms without any contraindications.
  1. 1. Psychiatric: history of schizophrenia, bipolar disorder, substance/alcohol abuse disorder, current elevated suicide risk, prior psychosurgery, prior ECT.
  2. 2. Neurologic: severe neurocognitive disorder, seizure disorder, certain structural brain lesions (e.g., intracranial mass lesions, hydrocephalus, sequelae of meningitis, frank brain injury).
  3. 3. TMS contraindications: implanted device; presence of metal in the head, including eyes and ears (excluding dental implants); certain tics; medications or systemic illness that predispose seizure risk; family history of 1st degree relative with seizure disorder.
  4. 4. Subjects with an unstable physical, systemic, or metabolic disorder (e.g., unstable hypertension, malnutrition secondary to eating disorder).
  5. 5. Females who are pregnant or nursing (as determined by a questionnaire and pregnancy test).
  6. 6. Current and anticipated continued treatment with excluded medication (See prohibited list).
  7. 7. Inability to complete the research protocol as determined by the Principal Investigator.

Contacts and Locations

Study Contact

Starlette Khim, BA
CONTACT
415-514-5743
ocdteenTMS@ucsf.edu

Principal Investigator

James T McCracken, MD
PRINCIPAL_INVESTIGATOR
University of California, San Francisco

Study Locations (Sites)

University of California, San Francisco
San Francisco, California, 94107
United States

Collaborators and Investigators

Sponsor: University of California, San Francisco

  • James T McCracken, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-06-01
Study Completion Date2027-07-01

Study Record Updates

Study Start Date2025-06-01
Study Completion Date2027-07-01

Terms related to this study

Keywords Provided by Researchers

  • Adolescent
  • transcranial magnetic stimulation

Additional Relevant MeSH Terms

  • Obsessive-Compulsive Disorder