The purpose of this study is to look at safety, tolerability, and pharmacodynamic effects (i.e. how the study drug affects your body) of PF-07258669 in older participants ((60 years to \<90 years) including those at risk of malnutrition. The study medicine PF-07258669 is being developed for the treatment of unintended weight loss in older adults. People with this condition have decreased appetite and food intake, which is an important reason for poor nutrition and health results in people with unintended weight loss. This is approximately a 26-week-long study with 9 visits to the study doctor and 4 telehealth visits (ie. visits by phone call). The study will include * Screening period for up to 4 weeks * Pre-treatment period of 2 weeks * Treatment period of 16 weeks : study drug (PF-07258669 or matching placebo) * Follow-up period of 4 weeks The study requires answering questionnaires and use of digital devices at home to measure blood pressure and physical activity. The study team will monitor how each participant is doing during the study
The purpose of this study is to look at safety, tolerability, and pharmacodynamic effects (i.e. how the study drug affects your body) of PF-07258669 in older participants ((60 years to \<90 years) including those at risk of malnutrition. The study medicine PF-07258669 is being developed for the treatment of unintended weight loss in older adults. People with this condition have decreased appetite and food intake, which is an important reason for poor nutrition and health results in people with unintended weight loss. This is approximately a 26-week-long study with 9 visits to the study doctor and 4 telehealth visits (ie. visits by phone call). The study will include * Screening period for up to 4 weeks * Pre-treatment period of 2 weeks * Treatment period of 16 weeks : study drug (PF-07258669 or matching placebo) * Follow-up period of 4 weeks The study requires answering questionnaires and use of digital devices at home to measure blood pressure and physical activity. The study team will monitor how each participant is doing during the study
A Study to Learn About the Study Medicine Called PF-07258669 in Older Adults Including Those at Risk of Malnutrition
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JEM Research Institute, Atlantis, Florida, United States, 33462
De La Cruz Research Center, LLC, Miami, Florida, United States, 33184
Headlands Research Orlando, Orlando, Florida, United States, 32819
Shields MRI Brockton, Brockton, Massachusetts, United States, 02301
Headlands Eastern MA LLC, Plymouth, Massachusetts, United States, 02360
AA Medical Research Center, Flint, Michigan, United States, 48504
Clinical Research Professionals, Chesterfield, Missouri, United States, 63005
Javara - Nevada Health Centers - Carson City, Carson City, Nevada, United States, 89706
Circuit Clinical, Secaucus, New Jersey, United States, 07094
Circuit Clinical /North Hudson Community Action Corporation, New York, New York, United States, 07093
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
60 Years to 89 Years
ALL
Yes
Pfizer,
Pfizer CT.gov Call Center, STUDY_DIRECTOR, Pfizer
2026-10-25