RECRUITING

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Description

A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).

Conditions

AfibSleep Apnea Syndrome, ObstructiveCPAP
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Related Conditions:

AfibSleep Apnea Syndrome, ObstructiveCPAP

Study Overview

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Study Details

Study overview

A pilot N-of-1 randomized controlled trial evaluating the effectiveness of a personalized CPAP intervention in reducing atrial fibrillation (AF) burden and improving AF-related quality of life in patients with moderate to severe obstructive sleep apnea (OSA).

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Sleep Apnea Triggers of Atrial Fibrillation: N-of-1 Randomized Control Trial (SPARTA):

Condition
Afib
Intervention / Treatment

-

Contacts and Locations

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Seattle

University of Washington, Seattle, Washington, United States, 98195

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Informed consent
  • 2. Age 18-85 years
  • 3. High burden paroxysmal AF (≥1%)
  • 4. Moderate-severe OSA (AHI ≥ 15)
  • 5. Implanted device with atrial diagnostics
  • 6. Enrolled in remote monitoring
  • 1. AF ablation \<6 months
  • 2. Valvular abnormalities
  • 3. Excessive daytime sleepiness in safety-critical jobs
  • 4. Plans for ablation during study
  • 5. Non-CPAP OSA treatment
  • 6. Recent device implantation (\<6 months)
  • 7. Central sleep apnea

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The Cleveland Clinic,

Study Record Dates

2026-05-31