RECRUITING

Evaluate the Effects of Citicoline on Mood in Healthy Adults

Conditions

Healthy Cognitive Citicoline Cognitive performance Mood

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objective of this trial is to determine the effects of citicoline on mood in healthy Men and Women compared to a placebo.

Official Title

Exploring the Effects of Citicoline Supplementation on Validated Subjective and Objective Markers of Mood in Healthy Volunteers: A Randomized, Double-blind, Placebo-controlled, Parallel-group Trial

Quick Facts

Study Start:2025-07-31

Study Completion:2026-03-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT07089238

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 65 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Provide voluntary signed and dated informed consent. * Be in good health and able to participate as determined by medical history and routine blood chemistries. * Biological men and women between 21 and 65 years of age (inclusive). * Body Mass Index of 18.5-32.0 (inclusive). * Body weight of at least 110 pounds. * Participant is experiencing moderate levels of mood disturbance during screening. * Normotensive (seated, resting systolic blood pressure \<140 mm Hg and diastolic blood pressure \< 90 mm Hg. * Normal supine, resting heart rate (\<90 per minute). * Agrees to maintain their existing dietary and physical activity patterns throughout the study period. * Participants agree to maintain their usual caffeine consumption habits, given that they do not exceed the maximum intake per day (400mg/day or 3-4 cups of coffee per day). * If a dietary supplement was initiated within the past month, the participant is willing to discontinue supplement use followed by a 2-week washout prior to participation in the study. * Willing to duplicate their previous 24-hour diet, refrain from caffeine for 24 hours, refrain from alcohol and exercise for 24 hours prior to each trial, and fast for 10 hours prior to each visit.	* QIDS (Quick Inventory of Depressive Symptomology) score \> 16. * Women who are pregnant, lactating, or planning to become pregnant during the study. Women must have a negative pregnancy test at screening. * Women with a PSST (Premenstrual Symptoms Screening Tool) score ≥30 * Current smokers or cessation within 3 months prior to screening. * Alcohol consumption (\>2 standard alcoholic drinks/day or \>10 drinks/week) or drug abuse/dependence. * Current use of any nootropic dietary supplements (e.g., GABA, Ashwaghanda, St. John's Wort, Ginkgo biloba, L-theanine, choline, Lion's mane, creatine, etc.) or medications (e.g., piracetam, Adderall, modafinil, etc.) that may confound the study or its endpoints. * Medical history of hepatorenal, musculoskeletal, autoimmune, or neurologic disease. * Individuals who have been diagnosed with digestive, liver, renal, cardiovascular, or other metabolic diseases. * Other known gastrointestinal or metabolic diseases that might impact nutrient absorption, distribution, metabolism, or excretion (e.g., intestinal malabsorption, electrolyte abnormalities, diabetes, thyroid disease, adrenal disease, hypogonadism, short bowel syndrome, diarrheal illnesses, history of colon resection, gastric ulcer, reflux disease, gastroparesis, Inborn-Errors-of-Metabolism, etc.). * Chronic medically diagnosed inflammatory condition or disease (e.g., rheumatoid arthritis, Crohn's disease, ulcerative colitis, Lupus, HIV/AIDS, etc.). * Medical history of a cognitive (i.e., ADD/ADHD) or psychiatric disorder, or brain-related medical conditions (e.g., TBI, ADHD). * Currently using medications to treat anxiety or depression. * Have an irregular sleep pattern (i.e. shift workers) or inadequate sleep schedule (i.e., less than 6 hours per night). * Known sensitivity, allergy, or intolerability to any ingredient in the test products. * Participants who report a clinically significant illness within the last 30 days. * Individuals who are cognitively impaired and/or who are unable to give informed consent. * Any other diseases or conditions that, in the opinion of the Principal Investigator, could confound the primary endpoint or place the subject at increased risk of harm if they were to participate.

Inclusion Criteria

Exclusion Criteria

* Provide voluntary signed and dated informed consent.
* Be in good health and able to participate as determined by medical history and routine blood chemistries.
* Biological men and women between 21 and 65 years of age (inclusive).
* Body Mass Index of 18.5-32.0 (inclusive).
* Body weight of at least 110 pounds.
* Participant is experiencing moderate levels of mood disturbance during screening.
* Normotensive (seated, resting systolic blood pressure \<140 mm Hg and diastolic blood pressure \< 90 mm Hg.
* Normal supine, resting heart rate (\<90 per minute).
* Agrees to maintain their existing dietary and physical activity patterns throughout the study period.
* Participants agree to maintain their usual caffeine consumption habits, given that they do not exceed the maximum intake per day (400mg/day or 3-4 cups of coffee per day).
* If a dietary supplement was initiated within the past month, the participant is willing to discontinue supplement use followed by a 2-week washout prior to participation in the study.
* Willing to duplicate their previous 24-hour diet, refrain from caffeine for 24 hours, refrain from alcohol and exercise for 24 hours prior to each trial, and fast for 10 hours prior to each visit.

* QIDS (Quick Inventory of Depressive Symptomology) score \> 16.
* Women who are pregnant, lactating, or planning to become pregnant during the study. Women must have a negative pregnancy test at screening.
* Women with a PSST (Premenstrual Symptoms Screening Tool) score ≥30
* Current smokers or cessation within 3 months prior to screening.
* Alcohol consumption (\>2 standard alcoholic drinks/day or \>10 drinks/week) or drug abuse/dependence.
* Current use of any nootropic dietary supplements (e.g., GABA, Ashwaghanda, St. John's Wort, Ginkgo biloba, L-theanine, choline, Lion's mane, creatine, etc.) or medications (e.g., piracetam, Adderall, modafinil, etc.) that may confound the study or its endpoints.
* Medical history of hepatorenal, musculoskeletal, autoimmune, or neurologic disease.
* Individuals who have been diagnosed with digestive, liver, renal, cardiovascular, or other metabolic diseases.
* Other known gastrointestinal or metabolic diseases that might impact nutrient absorption, distribution, metabolism, or excretion (e.g., intestinal malabsorption, electrolyte abnormalities, diabetes, thyroid disease, adrenal disease, hypogonadism, short bowel syndrome, diarrheal illnesses, history of colon resection, gastric ulcer, reflux disease, gastroparesis, Inborn-Errors-of-Metabolism, etc.).
* Chronic medically diagnosed inflammatory condition or disease (e.g., rheumatoid arthritis, Crohn's disease, ulcerative colitis, Lupus, HIV/AIDS, etc.).
* Medical history of a cognitive (i.e., ADD/ADHD) or psychiatric disorder, or brain-related medical conditions (e.g., TBI, ADHD).
* Currently using medications to treat anxiety or depression.
* Have an irregular sleep pattern (i.e. shift workers) or inadequate sleep schedule (i.e., less than 6 hours per night).
* Known sensitivity, allergy, or intolerability to any ingredient in the test products.
* Participants who report a clinically significant illness within the last 30 days.
* Individuals who are cognitively impaired and/or who are unable to give informed consent.
* Any other diseases or conditions that, in the opinion of the Principal Investigator, could confound the primary endpoint or place the subject at increased risk of harm if they were to participate.

Contacts and Locations

Study Contact

Tim Ziegenfuss, Ph.D., CSCS, FISSN

CONTACT

519-341-3367

tz@appliedhealthsciences.org

Study Locations (Sites)

The Center for Applied Health Sciences

Canfield, Ohio, 44406

United States

Collaborators and Investigators

Sponsor: Kirin Holdings Company, Limited

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-07-31

Study Completion Date2026-03-31

Study Record Updates

Study Start Date2025-07-31

Study Completion Date2026-03-31

Terms related to this study

Keywords Provided by Researchers

Cognitive
Citicoline
Cognitive performance
Mood

Additional Relevant MeSH Terms

Healthy