RECRUITING

A Study of Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

A single-group, multi-center, non-randomized clinical trial will be conducted to assess the feasibility of implementing an enhanced virtual world-based cardiac rehabilitation (VWCR) program within a muti-site clinical trial.

Official Title

Destination Cardiac Rehab: A Multicenter Feasibility Clinical Trial of an Enhanced Virtual World-based Cardiac Rehabilitation Intervention to Improve Cardiovascular Health and Outcomes Among Cardiac Patients

Quick Facts

Study Start:2025-10

Study Completion:2027-08

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT07095504

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Indication for CR according to Centers for Medicare \& Medicaid Services (CMS) guidelines (diagnosed within the preceding 12 months) to include one or more of the following: * Myocardial infarction * Coronary artery bypass surgery * Current stable angina (chest pain) * Heart valve repair or replacement * Percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting * Heart or heart-lung transplant * Stable chronic heart failure * Receiving care at one of the participating CR centers * Age ≥18 years * Basic Internet navigation skills * Active email address * Access to Internet at home or public access (church, library, etc) for 3 virtual visits per week	* High risk patients according to the AACVPR risk stratification given safety concern of unsupervised exercise * Patients receiving continuous inotropic support * Recent receipt of a mechanical support device * Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia) * Decompensated heart failure * Symptomatic valvular heart disease * Uncontrolled angina * Receiving continuous inotropic support * Presence of a mechanical circulatory support device * Decompensated heart failure * Symptomatic valvular heart disease * Uncontrolled angina * Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia) given safety concern of unsupervised exercise * Pregnancy (due to associated hormonal and weight changes) per patient report * Visual/hearing impairment or mental disability that would preclude independent use of the VW platform * Non-English-speaking patients due to logistical challenges with real time translation over a virtual platform

Inclusion Criteria

Exclusion Criteria

* Indication for CR according to Centers for Medicare \& Medicaid Services (CMS) guidelines (diagnosed within the preceding 12 months) to include one or more of the following:
* Myocardial infarction
* Coronary artery bypass surgery
* Current stable angina (chest pain)
* Heart valve repair or replacement
* Percutaneous transluminal coronary angioplasty (PTCA) or coronary stenting
* Heart or heart-lung transplant
* Stable chronic heart failure
* Receiving care at one of the participating CR centers
* Age ≥18 years
* Basic Internet navigation skills
* Active email address
* Access to Internet at home or public access (church, library, etc) for 3 virtual visits per week

* High risk patients according to the AACVPR risk stratification given safety concern of unsupervised exercise
* Patients receiving continuous inotropic support
* Recent receipt of a mechanical support device
* Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia)
* Decompensated heart failure
* Symptomatic valvular heart disease
* Uncontrolled angina
* Receiving continuous inotropic support
* Presence of a mechanical circulatory support device
* Decompensated heart failure
* Symptomatic valvular heart disease
* Uncontrolled angina
* Presence of hemodynamically unstable dysrhythmias (e.g., ventricular tachycardia) given safety concern of unsupervised exercise
* Pregnancy (due to associated hormonal and weight changes) per patient report
* Visual/hearing impairment or mental disability that would preclude independent use of the VW platform
* Non-English-speaking patients due to logistical challenges with real time translation over a virtual platform

Contacts and Locations

Study Contact

Lainey Moen, M.A.

CONTACT

507-266-7062

moen.lainey@mayo.edu

Principal Investigator

LaPrincess Brewer, M.P.H.

PRINCIPAL_INVESTIGATOR

Mayo Clinic

Study Locations (Sites)

University of California (UCI), Irvine

Irvine, California, 92617

United States

Mayo Clinic

Jacksonville, Florida, 32224

United States

Mayo Clinic

Rochester, Minnesota, 55905

United States

Collaborators and Investigators

Sponsor: Mayo Clinic

LaPrincess Brewer, M.P.H., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-10

Study Completion Date2027-08

Study Record Updates

Study Start Date2025-10

Study Completion Date2027-08

Terms related to this study

Additional Relevant MeSH Terms

Cardiovascular Health