RECRUITING

Image Detection of Impaired Microcirculatory Reperfusion

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain. These blood clots interrupt the normal flow of blood and oxygen to the nerve cells in the brain. When this occurs, the nerve cells can die, causing permanent damage to that area of the brain. That damage can result in loss of normal function to a patient's vision, strength, sensation, balance, or speech. These changes can remain permanent if blood flow is not restored to the brain. Thankfully, there are treatments available to help get rid of these blood clots. One of these treatments is a procedure to physically remove the blood clot causing stroke. This practice is now routinely done at all major stroke centers. Special imaging for stroke is now available at these major stroke centers. This imaging looks at blood flow in and around the area of brain that is dying. By performing these scans after the procedure, we can see that not all of brain is being saved by the procedure. That is a problem, because we know that saving brain cells can make a big difference in how patients recover from stroke. The purpose of this study is to determine which brain tissue will not get saved by blood clot removal. We will do this by using specialized imaging after the procedure. The study will discover if there is more brain tissue that can be saved after the procedure. Once we can determine this, our next steps will be looking at ways to save this tissue in the studies that follow. For example, we will look to see if medications can be given after the procedure to help save those brain areas. This study lays the groundwork for future studies to help save all the brain tissue we possibly can from dying during the stroke. This is our best chance of getting all patients affected by stroke the opportunity to live their best lives after stroke.

Official Title

Image Detection of Impaired Microcirculatory Reperfusion

Quick Facts

Study Start:2024-09-30
Study Completion:2027-03-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07099599

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults greater than or equal to 18 years of age
  2. * Last known normal (LKN) within 24 hours
  3. * Ischemic stroke due to anterior circulation LVO (intracranial internal carotid artery \[ICA\], proximal middle cerebral artery \[M1\], M1/M2 bifurcation, or proximal dominant M2 occlusion)
  4. * mTICI2c or mTICI3 on digital subtracted angiography (DSA) following mechanical thrombectomy
  1. * Significant renal insufficiency (glomerular filtration rate \<30mg/ml/min2 while not on dialysis)
  2. * Contraindication to iodinated contrast
  3. * Contraindication to magnetic resonance imaging (e.g., pacemaker incompatibility)
  4. * Prior significant stroke in same vascular territory ipsilateral stroke
  5. * Tandem vessel occlusion (i.e., extracranial ICA and ipsilateral intracranial M1/M2 occlusion)
  6. * Greater than 4 clot retrieval attempts
  7. * Enrollment in another acute stroke interventional study (with the exception of thrombectomy device registries)
  8. * Pregnancy
  9. * Prisoners

Contacts and Locations

Study Contact

Yasmin N Aziz, MD
CONTACT
513-688-5405
azizyn@ucmail.uc.edu
Christina Mihova
CONTACT

Study Locations (Sites)

University of Cincinnati
Cincinnati, Ohio, 45219
United States

Collaborators and Investigators

Sponsor: University of Cincinnati

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-09-30
Study Completion Date2027-03-31

Study Record Updates

Study Start Date2024-09-30
Study Completion Date2027-03-31

Terms related to this study

Keywords Provided by Researchers

  • No Reflow
  • Microcirculatory Reperfusion
  • Ischemic Stroke

Additional Relevant MeSH Terms

  • Ischemic Stroke, Acute
  • Large Vessel Occlusion