RECRUITING

Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Cesarean delivery is a commonly performed surgical procedure associated with worse postpartum pain when compared to vaginal birth. Uncontrolled postpartum pain is associated with increased neonatal and maternal risks. Multimodal non-opioid pain medications, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) are the preferred first-line therapies. There is no standard practice, however, on best dosing schedules (ie staggered or different time v. simultaneous or same time). This protocol describes a randomized clinical trial aimed to determine whether staggered dosing of acetaminophen and NSAIDs in superior to simultaneous dosing in controlling post-cesarean pain.

Official Title

PACESS: Post-cesarean Analgesia: Comparing Effectiveness of Staggered v. Simultaneous Therapies

Quick Facts

Study Start:2025-08-26
Study Completion:2027-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07102641

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:16 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * \>/= 34 weeks gestation
  2. * Singleton pregnancy
  3. * Delivery via cesarean section under regional anesthesia
  1. * Contraindication to acetaminophen or NSAIDs
  2. * Current or history of opioid use or misuse
  3. * Intrauterine fetal demise
  4. * Major congenital anomaly
  5. * Conversion to general anesthesia intra-op or planned general anesthesia
  6. * Mid-line vertical skin incision
  7. * Receipt of intraoperative local analgesia such as Transversus Abdominis Plan (TAP) block or wound infiltration

Contacts and Locations

Study Contact

Whitney Bender, MD
CONTACT
434-294-8416
whitney.bender@jefferson.edu
Brandy Firman
CONTACT
215-586-1656
brandy.firman@jefferson.edu

Study Locations (Sites)

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States

Collaborators and Investigators

Sponsor: Thomas Jefferson University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-26
Study Completion Date2027-12

Study Record Updates

Study Start Date2025-08-26
Study Completion Date2027-12

Terms related to this study

Additional Relevant MeSH Terms

  • Cesarean Delivery
  • Postpartum Comfort
  • Postpartum Pain
  • Post-operative Pain
  • NSAIDs
  • Acetaminophen (D000082)