COMPLETED

Hypnosis-Based Machine Learning Biomarker Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study seeks to contribute to the growing body of literature on hypnosis by providing robust, data-driven insights into the physiological mechanisms underlying trance states. The integration of electroencephalogram (EEG) and other wearable-derived physiological data will offer a comprehensive assessment of the changes that occur during a standardized hypnosis protocol: the Harvard Group Scale of Hypnotic Susceptibility (HGSHS:A). The results of this study are intended to facilitate derivation and validation of an Artificial Intelligence/Machine Learning (AI/ML)-based monitor that quantifies a patient's instantaneous emotional/arousal state along the spectrum that spans anxiety through states of calmness and trance. Future investigations will explore the ability of using such an interactive virtual system as a component of a closed-loop adaptive device to create optimal states of non-pharmacological sedation using personalized audiovisual content to allay anxiety and discomfort during medical procedures, such as percutaneous biopsies.

Official Title

Standardized Hypnotic Susceptibility Testing to Facilitate Development of a Machine Learning Tool to Characterize Physiological Biomarkers of Calm and Tranced States

Quick Facts

Study Start:2025-08-04
Study Completion:2025-09-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT07102810

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Written informed consent obtained from participant and ability and willingness for participant to comply with the requirements of the study.
  2. * Adults of all genders, ages 18-65
  3. * Healthy volunteers
  4. * English-speaking
  1. * Participating currently in experimental drug trials.
  2. * Recent (\<1 year) or current history of substance use disorder.
  3. * Diabetes T1 or T2, major cardiovascular or respiratory diseases, major neurological diseases, or limited mobility
  4. * Presence of a condition or abnormality that in the opinion of the investigator would compromise the safety of the patient or the quality of the data.
  5. * Adults that cannot consent.
  6. * Chronic use of psychoactive medications.
  7. * Chronic use of antiepileptic medications.
  8. * Active substance use disorder.
  9. * Participants reporting significant phobias or anxiety disorders triggered by imagery or situations involving insects (specifically flies), enclosed spaces or elevators (claustrophobia), or heights (acrophobia).

Contacts and Locations

Principal Investigator

David L Reich, MD
PRINCIPAL_INVESTIGATOR
Icahn School of Medicine at Mount Sinai Hospital

Study Locations (Sites)

Mount Sinai Hospital
New York, New York, 10029
United States

Collaborators and Investigators

Sponsor: Icahn School of Medicine at Mount Sinai

  • David L Reich, MD, PRINCIPAL_INVESTIGATOR, Icahn School of Medicine at Mount Sinai Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-04
Study Completion Date2025-09-09

Study Record Updates

Study Start Date2025-08-04
Study Completion Date2025-09-09

Terms related to this study

Keywords Provided by Researchers

  • Hypnosis
  • Trance
  • Anxiety
  • Machine Learning
  • Calm

Additional Relevant MeSH Terms

  • Disorder; Trance
  • Anxiety