RECRUITING

Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventila

Description

This is a pilot study to determine if pulmonary function (lung compliance and ventilation/perfusion matching) is improved using APRV during general anesthesia, compared to the standard CMV. APRV will be tested during anesthesia in 12 patients undergoing robotic-assisted gynecological or genitourinary surgical procedures for definitive cancer treatment, who will also receive CMV.

Conditions

Gynecologic CancerGenitourinary Cancer
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Related Conditions:

Gynecologic CancerGenitourinary Cancer

Study Overview

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Study Details

Study overview

This is a pilot study to determine if pulmonary function (lung compliance and ventilation/perfusion matching) is improved using APRV during general anesthesia, compared to the standard CMV. APRV will be tested during anesthesia in 12 patients undergoing robotic-assisted gynecological or genitourinary surgical procedures for definitive cancer treatment, who will also receive CMV.

Pilot Study to Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventilation (CMV) During Anesthesia for Robotic-Assisted Gynecological and Genitourinary Operative Procedures

Compare Airway Pressure Release Ventilation (APRV) to Conventional Mechanical Ventila

Condition
Gynecologic Cancer
Intervention / Treatment

-

Contacts and Locations

Tampa

Moffitt Cancer Center, Tampa, Florida, United States, 33612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants must have histologically or cytologically confirmed gynecological or genitourinary cancer.
  • * Subjects will have the physiologic reserve to undergo a robotic-assisted gynecological or genitourinary surgical procedure that uses anesthesia via Airway Pressure Release Ventilation and via Conventional Mechanical Ventilation.
  • * Adults (≥18 years old)
  • * ECOG performance status ≤ 2.
  • * Ability to understand and the willingness to sign a written informed consent document.
  • * Vulnerable subjects will not be enrolled for this study.
  • * Patients who have COPD and are on oxygen at home or who have COPD requiring routine daily inhalers or daytime oxygen are excluded.
  • * Patients who have history of major lung resection are excluded.
  • * Patients with body mass index (BMI) \>50 are excluded.
  • * Patients with pulmonary infection within the past 2 months of screening are excluded.
  • * The availability of oxygen to a fetus during this experimental procedure has not been established. Therefore, patients known to be pregnant per operating room (OR) policy will be excluded.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

H. Lee Moffitt Cancer Center and Research Institute,

David Thrush, MD, PRINCIPAL_INVESTIGATOR, Moffitt Cancer Center

Study Record Dates

2026-07