Feasibility of Home-Based Intermittent 60Hz Light Therapy for Major Depressive Disorder (MDD)

Eligibility Criteria

• * Age between 24 and 65 years (inclusive)\*.
• * Confirmed diagnosis of Major Depressive Disorder (MDD), based on MINI interview.
• * Hamilton Depression Rating Scale (HDRS-17) score ≥17 at screening.
• * On a stable dose of antidepressant medication for at least 30 days prior to HDRS-17 screening.
• * No evidence of premorbid cognitive impairment, as demonstrated by a standard score \>85 on the WRAT-5 Reading Recognition Subtest.
• * Confirmed access to a local provider that has primary responsibility for the subjects' clinical care, and who is available for contact in case of increased subject risk due to depressive symptoms.
• * Able to provide informed consent and comply with study procedures.
• * Access to a quiet space suitable for home-based light stimulation sessions.
• * English speaking: All study materials and assessments are only validated in English
• * Presence of primary neurological or autoimmune disorders.
• * Presence of psychiatric comorbidities as determined by the MINI interview (e.g., anxiety disorders, OCD, PTSD, bipolar disorder, psychotic disorder).
• * Current or recent diagnosis of alcohol or substance use disorder.
• * History of bipolar disorder or any psychotic disorder.
• * Clinically significant suicidal ideation or behavior, based on clinician judgment and the Columbia-Suicide Severity Rating Scale (C-SSRS).
• * History of seizure disorder or epilepsy.
• * History of migraine, tinnitus, or photosensitivity.
• * Diagnosis of retinal disease, cataract, or other visual impairments that may interfere with light exposure.
• * Regular use of anti-inflammatory drugs or anticoagulants (e.g., clopidogrel).
• * Pregnancy and Breastfeeding: Currently pregnant, planning pregnancy during the study period, or breastfeeding