RECRUITING

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This phase I trial is evaluating a new imaging tracer (68Ga-FAPi-46) with positron emission tomography (PET)/computed tomography (CT) to determine where and to which degree the tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues (the biodistribution) in patients with solid tumors or hematologic (blood) cancers. PET is an established imaging technique that utilizes small amounts of radioactivity attached to very minimal amounts of tracer, in the case of this research, 68Ga-FAPi-46. Because some cancers take up 68Ga-FAPi-46, it can be seen with PET. CT utilizes x-rays that traverse the body from the outside. CT images provide an exact outline of organs and potential inflammatory tissue where it occurs in a patient's body. Combining a PET scan with a CT scan can help make the image easier to interpret. PET/CT scans are hybrid scanners that combine both modalities into a single scan during the same examination.

Official Title

PET Imaging Study of 68Ga-FAPI-46 Biodistribution in Cancer Patients

Quick Facts

Study Start:2025-08-01
Study Completion:2027-09-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07118176

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with the following suspected or diagnosed cancer types:
  2. * Adrenal cancer
  3. * Anal cancer
  4. * Bladder cancer
  5. * Brain cancer
  6. * Breast cancer
  7. * Cancer of unknown primary (CUP)
  8. * Cervical cancer
  9. * Cholangiocarcinoma
  10. * Colorectal cancer
  11. * Esophageal cancer
  12. * Gastric cancer
  13. * Head and neck cancer
  14. * Hematologic cancer
  15. * Hepatocellular carcinoma
  16. * Lung cancer
  17. * Medullary thyroid cancer
  18. * Neuroendocrine neoplasias
  19. * Ovarian cancer
  20. * Pancreatic cancer
  21. * Penile cancer
  22. * Peritoneal cancer
  23. * Pleural cancer
  24. * Prostate cancer
  25. * Sarcoma
  26. * Salivary gland cancer
  27. * Solitary fibrous tumor
  28. * Skin cancer
  29. * Testicular cancer
  30. * Thymus cancer
  31. * Thyroid cancer
  32. * Urothelial cancer
  33. * Uterus cancer
  34. * Vaginal cancer
  35. * Patients are ≥ 18 years old at the time of the radiotracer administration
  36. * Patient can provide written informed consent
  37. * Patient is able to remain still for duration of imaging procedure (up to one hour)
  1. * Patient is pregnant or nursing
  2. * Patient has underlying disease which, based on the judgment of the investigator, might interfere with the collection of high-quality data

Contacts and Locations

Principal Investigator

Jeremie Calais
PRINCIPAL_INVESTIGATOR
UCLA / Jonsson Comprehensive Cancer Center

Study Locations (Sites)

UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095
United States

Collaborators and Investigators

Sponsor: Jonsson Comprehensive Cancer Center

  • Jeremie Calais, PRINCIPAL_INVESTIGATOR, UCLA / Jonsson Comprehensive Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-01
Study Completion Date2027-09-07

Study Record Updates

Study Start Date2025-08-01
Study Completion Date2027-09-07

Terms related to this study

Additional Relevant MeSH Terms

  • Anal Carcinoma
  • Bladder Carcinoma
  • Breast Carcinoma
  • Cervical Carcinoma
  • Cholangiocarcinoma
  • Colorectal Carcinoma
  • Esophageal Carcinoma
  • Gastric Carcinoma
  • Head and Neck Carcinoma
  • Hematopoietic and Lymphatic System Neoplasm
  • Hepatocellular Carcinoma
  • Lung Carcinoma
  • Malignant Adrenal Gland Neoplasm
  • Malignant Brain Neoplasm
  • Malignant Neoplasm of Unknown Primary
  • Malignant Solid Neoplasm
  • Malignant Testicular Neoplasm
  • Malignant Uterine Neoplasm
  • Neuroendocrine Neoplasm
  • Ovarian Carcinoma
  • Pancreatic Carcinoma
  • Penile Carcinoma
  • Pleural Carcinomatosis
  • Primary Peritoneal Carcinoma
  • Prostate Carcinoma
  • Salivary Gland Carcinoma
  • Sarcoma
  • Skin Carcinoma
  • Solitary Fibrous Tumor
  • Thymus Carcinoma
  • Thyroid Gland Carcinoma
  • Thyroid Gland Medullary Carcinoma
  • Urothelial Carcinoma
  • Vaginal Carcinoma