RECRUITING

Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM

Description

Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley catheter has not been evaluated in prospective studies on patients with PPROM.

Study Overview

Study Details

Study overview

Data on the optimal mode of labor induction after preterm prelabor rupture of membranes (PPROM) is lacking. Studies have shown no difference between oxytocin and misoprostol use for labor induction in this cohort (1). The preponderance of evidence from term pregnancies suggests that Foley catheter coupled with oxytocin is better than oxytocin alone, with a higher rate of delivery within 24 hours when a Foley catheter followed by oxytocin is compared to oxytocin alone. However, the use of a Foley catheter has not been evaluated in prospective studies on patients with PPROM.

Combination Oxytocin/Foley Versus Oxytocin Alone for Induction of Labor in Patients With Preterm Prelabor Rupture of Membranes

Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROM

Condition
Preterm PROM (Pregnancy)
Intervention / Treatment

-

Contacts and Locations

Norfolk

Sentara Norfolk General Hospital, Norfolk, Virginia, United States, 23507

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients 18-50 years of age;
  • * The patient is fluent in English, physically and mentally able to understand the informed consent, and is willing to participate in this study;
  • * PPROM;
  • * Cervical dilation \</= 2cm
  • * Fetal cephalic presentation;
  • * The patient is between 34 weeks 0 days and 36 weeks 6 days of gestation at the time of enrollment. Gestational age will be determined by last menstrual period, confirmed with a first trimester ultrasound, per the recommended guidelines by the American College of Obstetricians and Gynecologists.
  • * Spontaneous labor
  • * Known allergy to latex;
  • * Cervical dilation \>2cm;
  • * Chorioamnionitis;
  • * Contraindications to induction of labor or use of Foley for cervical ripening
  • * HIV
  • * Known or suspected fetal anomaly or aneuploidy;
  • * Prisoners.

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Eastern Virginia Medical School,

Marwan Ma'ayeh, MD, PRINCIPAL_INVESTIGATOR, Eastern Virginia Medical School

Study Record Dates

2026-12-30