RECRUITING

Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this observational study is to learn more about the biology of cervical cancer in women who receive radiation therapy for this condition. The main question it aims to answer is: Does radiation therapy alter the expression of tissue factor and other molecules in cervical cancer over time? Participants already scheduled for radiation therapy for cervical cancer as part of their regular medical care will provide blood and biopsies of cervical cancer or of the upper portion of the vagina before, during, and on the last day of radiation therapy.

Official Title

Understanding the Biological Drivers of Cervical Cancer and Side Effects From Radiation Therapy

Quick Facts

Study Start:2025-08-04
Study Completion:2027-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07121543

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 years or older
  2. * Pathological diagnosis of cervical cancer
  3. * Scheduled to receive brachytherapy for cervical cancer
  1. * Pregnancy or lactation
  2. * Inability to provide a tissue sample

Contacts and Locations

Study Contact

Jyoti Mayadev, MD
CONTACT
858-822-5354
CancerCTO@health.ucsd.edu
Erika Peterson
CONTACT
858-822-5354
CancerCTO@health.ucsd.edu

Principal Investigator

Jyoti Mayadev, MD
PRINCIPAL_INVESTIGATOR
University of California, San Diego

Study Locations (Sites)

University of California San Diego
La Jolla, California, 92093
United States

Collaborators and Investigators

Sponsor: University of California, San Diego

  • Jyoti Mayadev, MD, PRINCIPAL_INVESTIGATOR, University of California, San Diego

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08-04
Study Completion Date2027-08

Study Record Updates

Study Start Date2025-08-04
Study Completion Date2027-08

Terms related to this study

Keywords Provided by Researchers

  • Radiotherapy
  • Cervical cancer
  • Translational research
  • Biomarkers

Additional Relevant MeSH Terms

  • Cervical Cancer