RECRUITING

The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are: * Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation? * Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication? * Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?

Official Title

The Impact of GLP-1 Agonist and GIP Agonist on Bowel Preparation Quality: A Randomized Controlled Trial

Quick Facts

Study Start:2025-08
Study Completion:2026-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT07127354

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult patient (Age 18 years or older)
  2. * Patient scheduled for outpatient screening, surveillance, or diagnostic colonoscopy
  3. * Using a GLP-1 or GIP agonist at a stable dose for at least one month
  1. * Unable to provide informed consent, e.g., dementia
  2. * Patient refuses the USMSTF recommended bowel cleansing regimen for patients with diabetes or obesity (split-dose 4 liters polyethylene glycol + 15 mg bisacodyl the afternoon before; low residue diet 3 days before colonoscopy; clear liquid diet the day before colonoscopy)
  3. * Risk factors for inadequate bowel preparation besides diabetes and obesity with a likelihood ratio of 1.6 or greater:
  4. 1. Cirrhosis
  5. 2. Parkinson's disease
  6. 3. Dementia
  7. 4. Tricyclic antidepressant use
  8. 5. Opioid use
  9. 6. Gastroparesis\* or suspected gastric outlet obstruction on pre-procedure imaging (\*defined based on a documented 4-hour solid phase gastric emptying study or prior history of retained gastric contents during upper endoscopy)
  10. 7. Previous colorectal surgery
  11. 8. Prior history of inadequate bowel preparation

Contacts and Locations

Study Locations (Sites)

Cleveland Clinic
Cleveland, Florida, 44195
United States
Cleveland Clinic Weston
Weston, Florida, 33331
United States

Collaborators and Investigators

Sponsor: The Cleveland Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-08
Study Completion Date2026-08

Study Record Updates

Study Start Date2025-08
Study Completion Date2026-08

Terms related to this study

Keywords Provided by Researchers

  • GLP-1
  • Bowel preparation for colonoscopy

Additional Relevant MeSH Terms

  • GLP - 1
  • Bowel Preparation for Colonoscopy